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Table 2 Model statistics for responses

From: Pharmacoscintigraphic evaluation and antidiabetic efficacy of gliclazide-loaded 99mTc-labelled mucoadhesive microspheres

ANOVA of dependant variables

Dependant variables

Source of variables

Sum of squares

Degree of freedom

Mean square

F value

P value

Drug loading

Regression

Residuals

Total

R2

528.28

14.15

542.44

0.9739

2

6

8

264.14

2.36

111.98

 < 0.0001 Significant

Bio adhesion

Regression

Residuals

Total

R2

188.00

51.21

239.21

0.7859

2

6

8

94.00

8.53

11.01

0.0098 Significant

Drug release

Regression

Residuals

Total

R2

369.93

47.74

471.67

0.8857

2

6

8

184.96

7.96

23.25

0.0015 Significant

Model statistics

Model R2

R2

Adjusted R2

Predicted R2

PRESS

s.d

Remarks

Response Y1 (drug loading)

 Linear

0.9739

0.9652

0.9404

32.35

1.54

Suggested

 Interactive

0.9744

0.9591

0.8831

63.41

1.67

 

 Quadratic

0.9949

0.9864

0.9430

30.90

0.9587

 

Response Y3 (drug release)

 Linear

0.8857

0.8476

0.7211

116.49

2.82

Suggested

 Interactive

0.9139

0.8622

0.6090

163.30

2.68

 

 Quadratic

0.9748

0.9328

0.6929

128.25

1.87

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