Table 6 Pharmacokinetic parameters of the optimized formula (F8) an draw GLZ powder after oral administration to rats in a dose corresponding to 10Â mg/kg GLZ
Pk parameters | Gliclazide API | Gliclazide microspheres | ||
|---|---|---|---|---|
Mean | SD | Mean | SD | |
Cmax (µg/ml) | 2.013 | 0.035 | 14.407 | 0.300 |
Tmax (h) | 4.000 | 0.000 | 4.000 | 0.000 |
AUC 0_24 (µg*h/ml) | 26.108 | 0.217 | 105.870 | 0.731 |
AUC t_infi (µg*h/ml) | 47.586 | 1.482 | 127.516 | 0.857 |