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Table 6 Pharmacokinetic parameters of the optimized formula (F8) an draw GLZ powder after oral administration to rats in a dose corresponding to 10 mg/kg GLZ

From: Pharmacoscintigraphic evaluation and antidiabetic efficacy of gliclazide-loaded 99mTc-labelled mucoadhesive microspheres

Pk parameters Gliclazide API Gliclazide microspheres
Mean SD Mean SD
Cmax (µg/ml) 2.013 0.035 14.407 0.300
Tmax (h) 4.000 0.000 4.000 0.000
AUC 0_24 (µg*h/ml) 26.108 0.217 105.870 0.731
AUC t_infi (µg*h/ml) 47.586 1.482 127.516 0.857
  1. Data are expressed as mean ± SD