Characterization of novel stress degradation products of Bempedoic acid and Ezetimibe using UPLC–MS/MS: development and validation of stability-indicating UPLC method

Future Journal of Pharmaceutical Sciences

Table 4 UPLC precision results of (A) Bempedoic acid and (B) Ezetimibe

S. no.	Amount added (µg/ml)	Mean ± SD	% RSD
A
Method precision results
1	90	89.98 ± 0.011	0.36
2	180	180.14 ± 0.053	0.87
3	270	270.15 ± 0.074	0.65
Intermediate precision results of Day-1
1	90	90.15 ± 0.046	0.88
2	180	180.01 ± 0.035	0.53
3	270	270.08 ± 0.015	0.27
Intermediate precision results of Day-2
1	90	90.19 ± 0.024	0.74
2	180	179.99 ± 0.039	0.65
3	270	270.04 ± 0.055	0.39
Intermediate precision results of column-1
1	90	90.14 ± 0.052	0.61
2	180	0.07 ± 0.049	0.36
3	270	270.06 ± 0.078	0.34
Intermediate precision results of column-2
1	90	90.11 ± 0.025	0.91
2	180	180.07 ± 0.034	0.68
3	270	270.06 ± 0.048	0.42
B
Method precision results
1	5	5.09 ± 0.035	0.74
2	10	10.05 ± 0.024	0.85
3	15	15.03 ± 0.049	0.34
Intermediate precision results of Day-1
1	5	4.99 ± 0.024	0.28
2	10	10.21 ± 0.047	0.42
3	15	15.14 ± 0.056	0.53
Intermediate precision results of Day-2
1	5	5.04 ± 0.041	0.46
2	10	10.17 ± 0.027	0.62
3	15	15.14 ± 0.011	0.28
Intermediate precision results of column-1
1	5	5.07 ± 0.024	0.465
2	10	9.97 ± 0.044	0.61
3	15	15.06 ± 0.021	0.38
Intermediate precision results of column-2
1	5	5.10 ± 0.024	0.28
2	10	10.07 ± 0.078	0.11
3	15	15.07 ± 0.039	0.96