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Table 4 UPLC precision results of (A) Bempedoic acid and (B) Ezetimibe

From: Characterization of novel stress degradation products of Bempedoic acid and Ezetimibe using UPLC–MS/MS: development and validation of stability-indicating UPLC method

S. no. Amount added (µg/ml) Mean ± SD % RSD
A
Method precision results
 1 90 89.98 ± 0.011 0.36
 2 180 180.14 ± 0.053 0.87
 3 270 270.15 ± 0.074 0.65
Intermediate precision results of Day-1
 1 90 90.15 ± 0.046 0.88
 2 180 180.01 ± 0.035 0.53
 3 270 270.08 ± 0.015 0.27
Intermediate precision results of Day-2
 1 90 90.19 ± 0.024 0.74
 2 180 179.99 ± 0.039 0.65
 3 270 270.04 ± 0.055 0.39
Intermediate precision results of column-1
 1 90 90.14 ± 0.052 0.61
 2 180 0.07 ± 0.049 0.36
 3 270 270.06 ± 0.078 0.34
Intermediate precision results of column-2
 1 90 90.11 ± 0.025 0.91
 2 180 180.07 ± 0.034 0.68
 3 270 270.06 ± 0.048 0.42
B    
Method precision results
 1 5 5.09 ± 0.035 0.74
 2 10 10.05 ± 0.024 0.85
 3 15 15.03 ± 0.049 0.34
Intermediate precision results of Day-1
 1 5 4.99 ± 0.024 0.28
 2 10 10.21 ± 0.047 0.42
 3 15 15.14 ± 0.056 0.53
Intermediate precision results of Day-2
 1 5 5.04 ± 0.041 0.46
 2 10 10.17 ± 0.027 0.62
 3 15 15.14 ± 0.011 0.28
Intermediate precision results of column-1
 1 5 5.07 ± 0.024 0.465
 2 10 9.97 ± 0.044 0.61
 3 15 15.06 ± 0.021 0.38
Intermediate precision results of column-2
 1 5 5.10 ± 0.024 0.28
 2 10 10.07 ± 0.078 0.11
 3 15 15.07 ± 0.039 0.96