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Table 6 Degradation results of Bempedoic acid and Ezetimibe

From: Characterization of novel stress degradation products of Bempedoic acid and Ezetimibe using UPLC–MS/MS: development and validation of stability-indicating UPLC method

Deg condition Time/Temp Bempedoic acid Ezetimibe Number of DPs formed
% Deg % Assay % MB % Deg % Assay % MB
Acid deg 3 h, 60 °C 16.4 86.1 102.5 11.6 89.6 101.2 DP1, DP2 and DP5
Alkali deg 3 h, 60 °C 17.7 81.8 99.5 13.6 87.2 100.8 DP1, DP2 and DP5
Peroxide deg 18.7 81.2 99.9 15.8 84.1 99.9 DP1, DP2, DP5 and DP7
Reduction deg 3 h, 60 °C 18.5 83.4 101.9 16.4 84.7 101.1 DP1
Thermal deg 24 h, 105 °C 16.3 85.3 101.6 16.6 84.8 101.4 DP1 and DP2
Photolytic deg UV–Vis light 16.2 83.5 99.7 16.8 83.9 100.7 DP1, DP3 and DP4