Table 6 Degradation results of Bempedoic acid and Ezetimibe
Deg condition | Time/Temp | Bempedoic acid | Ezetimibe | Number of DPs formed | ||||
|---|---|---|---|---|---|---|---|---|
% Deg | % Assay | % MB | % Deg | % Assay | % MB | |||
Acid deg | 3 h, 60 °C | 16.4 | 86.1 | 102.5 | 11.6 | 89.6 | 101.2 | DP1, DP2 and DP5 |
Alkali deg | 3 h, 60 °C | 17.7 | 81.8 | 99.5 | 13.6 | 87.2 | 100.8 | DP1, DP2 and DP5 |
Peroxide deg | – | 18.7 | 81.2 | 99.9 | 15.8 | 84.1 | 99.9 | DP1, DP2, DP5 and DP7 |
Reduction deg | 3 h, 60 °C | 18.5 | 83.4 | 101.9 | 16.4 | 84.7 | 101.1 | DP1 |
Thermal deg | 24 h, 105 °C | 16.3 | 85.3 | 101.6 | 16.6 | 84.8 | 101.4 | DP1 and DP2 |
Photolytic deg | UV–Vis light | 16.2 | 83.5 | 99.7 | 16.8 | 83.9 | 100.7 | DP1, DP3 and DP4 |