Future Journal of Pharmaceutical Sciences

Table 7 Method validation results of Bempedoic acid and Ezetimibe by UPLC

From: Characterization of novel stress degradation products of Bempedoic acid and Ezetimibe using UPLC–MS/MS: development and validation of stability-indicating UPLC method

Parameter	Bempedoic acid		Ezetimibe
Parameter	Concentration (µg/ml)	Result	Concentration (µg/ml)	Result
Linearity	18–360	CC: 0.999	1–20	CC: 0.999
Accuracy	90	% Rec: 100.1	5	%Rec: 99.5
	180	%Rec: 99.9	10	% Rec: 99.3
	270	% Rec: 99.6	15	% Rec: 99.9
Intraday precision	180	%RSD: 0.87	10	%RSD: 0.65
Interday precision	180	%RSD: 0.36	10	%RSD: 0.61
Robustness
Flow Plus Flow Minus	180 180	0.41 0.37	10 10	0.33 0.82
Organic Plus	180	0.78	10	0.51
Organic Minus	180	0.52	10	0.78
Wavelength Plus	180	0.42	10	0.84
Wavelength Minus	180	0.39	10	0.92

CC correlation coefficient
% REC-% Recovery
%RSD: Relative standard deviation

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