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Table 1 Composition of various microspheres prepared as per Box–Behnken design (BBD)

From: DoE approach for development of localized controlled release microspheres of Vancomycin for treatment of septic arthritis

Formulation

Drug concentration (X1)

Calcium chloride concentration (X2)

Stirring speed (X3)

Coded

Actual (mg)

Coded

Actual (mg)

Coded

Actual (rpm)

VMS 1

− 1

100

0

200

− 1

500

VMS 2

+ 1

300

0

200

+ 1

1500

VMS 3

+ 1

300

0

200

− 1

500

VMS 4

0

200

− 1

100

+ 1

1500

VMS 5

− 1

100

+ 1

300

0

1000

VMS 6

− 1

100

− 1

100

0

1000

VMS 7

0

200

+ 1

300

+ 1

1500

VMS 8

− 1

100

0

200

+ 1

1500

VMS 9

+ 1

300

+ 1

300

0

1000

VMS 10

0

200

− 1

100

− 1

500

VMS 11

+ 1

300

− 1

100

0

1000

VMS 12

0

200

+ 1

300

− 1

500

  1. VMS Vancomycin HCl microspheres