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Table 1 Composition of various microspheres prepared as per Box–Behnken design (BBD)

From: DoE approach for development of localized controlled release microspheres of Vancomycin for treatment of septic arthritis

Formulation Drug concentration (X1) Calcium chloride concentration (X2) Stirring speed (X3)
Coded Actual (mg) Coded Actual (mg) Coded Actual (rpm)
VMS 1 − 1 100 0 200 − 1 500
VMS 2 + 1 300 0 200 + 1 1500
VMS 3 + 1 300 0 200 − 1 500
VMS 4 0 200 − 1 100 + 1 1500
VMS 5 − 1 100 + 1 300 0 1000
VMS 6 − 1 100 − 1 100 0 1000
VMS 7 0 200 + 1 300 + 1 1500
VMS 8 − 1 100 0 200 + 1 1500
VMS 9 + 1 300 + 1 300 0 1000
VMS 10 0 200 − 1 100 − 1 500
VMS 11 + 1 300 − 1 100 0 1000
VMS 12 0 200 + 1 300 − 1 500
  1. VMS Vancomycin HCl microspheres