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Table 3 Statistical ANOVA results for contour and surface responses (Y1Y3)

From: DoE approach for development of localized controlled release microspheres of Vancomycin for treatment of septic arthritis

Source Sum of squares Df Mean squares F-value P value Remark
Particle size (Y1)
 Model 286.44 8 35.80 52.63 0.0039 Significant
 A: Drug 12.35 1 12.35 18.15 0.0237 Significant
 B: Hardening agent 22.04 1 22.04 32.40 0.0107 Significant
 C: Stirring speed 244.87 1 244.87 359.92 0.0003 Significant
 AB 0.0756 1 0.0756 0.1112 0.7608 Not significant
 AC 0.0110 1 0.0110 0.0162 0.9068 Not significant
 BC 5.78 1 5.78 8.50 0.0517 Significant
 A2 1.04 1 1.04 1.52 0.3049 Not significant
 B2 0.9112 1 0.9112 1.34 0.3309 Not significant
Entrapment efficiency (Y2)
 Model 1739.36 3 579.79 13.84 0.0016 Significant
 A: Drug 22.28 1 22.28 0.5319 0.4866 Not significant
 B: Hardening agent 548.47 1 548.57 13.09 0.0068 Significant
 C: Stirring speed 1168.62 1 1168.62 27.90 0.0007 Significant
Drug release (Y3)
 Model 379.23 6 6 14.73 0.0048 Significant
 A: Drug 14.96 1 1 3.49 0.1208 Not significant
 B: Hardening agent 29.22 1 1 6.81 0.0477 Significant
 C: Stirring speed 327.81 1 1 76.40 0.003 Significant
 AB 3.80 1 1 0.8863 0.3897 Not significant
 AC 1.49 1 1 0.3469 0.5815 Not significant
 BC 1.95 1 1 0.4536 0.5305 Not significant
  1. A = X1(Drug), B = X2(Hardening agent), C = X3(Stirring speed), AB = X1X2, BC = X2X3, AC = X1X3, A2 = X12, B2 = X22