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Table 3 Statistical ANOVA results for contour and surface responses (Y1Y3)

From: DoE approach for development of localized controlled release microspheres of Vancomycin for treatment of septic arthritis

Source

Sum of squares

Df

Mean squares

F-value

P value

Remark

Particle size (Y1)

 Model

286.44

8

35.80

52.63

0.0039

Significant

 A: Drug

12.35

1

12.35

18.15

0.0237

Significant

 B: Hardening agent

22.04

1

22.04

32.40

0.0107

Significant

 C: Stirring speed

244.87

1

244.87

359.92

0.0003

Significant

 AB

0.0756

1

0.0756

0.1112

0.7608

Not significant

 AC

0.0110

1

0.0110

0.0162

0.9068

Not significant

 BC

5.78

1

5.78

8.50

0.0517

Significant

 A2

1.04

1

1.04

1.52

0.3049

Not significant

 B2

0.9112

1

0.9112

1.34

0.3309

Not significant

Entrapment efficiency (Y2)

 Model

1739.36

3

579.79

13.84

0.0016

Significant

 A: Drug

22.28

1

22.28

0.5319

0.4866

Not significant

 B: Hardening agent

548.47

1

548.57

13.09

0.0068

Significant

 C: Stirring speed

1168.62

1

1168.62

27.90

0.0007

Significant

Drug release (Y3)

 Model

379.23

6

6

14.73

0.0048

Significant

 A: Drug

14.96

1

1

3.49

0.1208

Not significant

 B: Hardening agent

29.22

1

1

6.81

0.0477

Significant

 C: Stirring speed

327.81

1

1

76.40

0.003

Significant

 AB

3.80

1

1

0.8863

0.3897

Not significant

 AC

1.49

1

1

0.3469

0.5815

Not significant

 BC

1.95

1

1

0.4536

0.5305

Not significant

  1. A = X1(Drug), B = X2(Hardening agent), C = X3(Stirring speed), AB = X1X2, BC = X2X3, AC = X1X3, A2 = X12, B2 = X22