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Table 4 Result of the forced degradation study

From: A novel simultaneous high performance liquid chromatography-PDA method for the determination of Tenofovir AF, Darunavir, Emtricitabine and Cobicistat in bulk and its application to marketed formulation

Stressed conditions

Tenofovir

Darunavir

Emtricitabine

Cobicistat

% Degradation

Purity Angle

Purity Threshold

% Degradation

Purity Angle

Purity Threshold

% Degradation

Purity Angle

Purity Threshold

% Degradation

Purity Angle

Purity Threshold

Acid

3.64

0.169

1.009

3.31

0.137

1.013

4.67

0.223

1.005

5.08

0.144

1.012

Alkaline

3.10

0.308

1.672

3.70

0.654

1.857

3.13

0.126

1.152

4.57

0.193

1.642

Peroxided

3.46

0.206

1.034

7.51

0.423

1.797

3.76

0.735

1.310

6.24

0.190

1.856

Photolytic

3.92

0.289

1.673

4.89

0.486

1.538

7.74

0.187

1.563

5.49

0.397

1.675

Thermal

3.76

0.217

1.429

5.02

0.265

1.497

4.59

0.543

1.241

5.64

0.315

1.211