S. no. | Name of perilipins | Functional role |
---|---|---|
1 | Perilipin 1 | Lipid droplet size enlargement, deposition of neutral lipid, causes excessive fat deposition with Macro Hepatosteatosis condition, phosphorylation of PLIN 1 leads higher rate of lipolysis |
2 | Perilipin 2 | Express in mixed type hepatosteatosis, higher PLIN 2 expression leads SREBP activation, activation of lipid synthesis, maturation of lipid droplets from nascent |
3 | Perilipin 3 | Move cytosolic to nascent lipid droplets from ER lumen, Increase expression of Hepatitis C virus core protein, associated with inflammatory pathways like PGE2, COX-2, etc. |
4 | Perilipin 4 | PLIN-4 expressed like PLIN-3 in nascent lipid droplets, leads micro hepatosteatosis condition |
5 | Perilipin 5 | Micro Hepatosteatosis, over expression recruits mitochondria and increase beta oxidation, prevent direct cellular lipotoxicity |