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Table 1 Represents functional role of perilipins

From: Lipid droplets associated perilipins protein insights into finding a therapeutic target approach to cure non-alcoholic fatty liver disease (NAFLD)

S. no.

Name of perilipins

Functional role

1

Perilipin 1

Lipid droplet size enlargement, deposition of neutral lipid, causes excessive fat deposition with Macro Hepatosteatosis condition, phosphorylation of PLIN 1 leads higher rate of lipolysis

2

Perilipin 2

Express in mixed type hepatosteatosis, higher PLIN 2 expression leads SREBP activation, activation of lipid synthesis, maturation of lipid droplets from nascent

3

Perilipin 3

Move cytosolic to nascent lipid droplets from ER lumen, Increase expression of Hepatitis C virus core protein, associated with inflammatory pathways like PGE2, COX-2, etc.

4

Perilipin 4

PLIN-4 expressed like PLIN-3 in nascent lipid droplets, leads micro hepatosteatosis condition

5

Perilipin 5

Micro Hepatosteatosis, over expression recruits mitochondria and increase beta oxidation, prevent direct cellular lipotoxicity