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Table 6 Repeatability and intermediate precision of ESP and NAP

From: Analytical quality by design approach to RP-HPLC method development and validation for simultaneous estimation of esomeprazole and naproxen in modified-release dosage form

 

Mean value of three replicate injections of NAP

80% Concentration

100% Concentration

120% Concentration

RT

Peak area

RT

Peak area

RT

Peak area

Intra-day precision

5.95

1,124,957

5.93

1,401,766

5.94

1,691,046

Inter-day precision

5.97

1,124,636

5.96

1,401,854

5.93

1,691,849

% RSD

0.02

0.02

0.00

0.00

0.03

0.03

 

Mean value of three replicate injections of ESP

80% Concentration

100% Concentration

120% Concentration

RT

Peak area

RT

Peak area

RT

Peak area

Intra-day precision

9.04

72,647

9.00

89,263

9.04

105,819

Inter-day precision

9.04

72,379

9.02

89,304

9.05

106,398

% RSD

0.03

0.08

0.21

0.03

0.10

0.39

  1. Repeatability and Intermediate Precision have been assessed using 3 concentration/3 replicates each