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Table 3 Effect of ethanolic extract of L. rugosa on liver function enzymes in paracetamol-induced hepatotoxicity in rats

From: Ameliorative effect of ethanolic extract of Limnophila rugosa (Scrophulariaceae) in paracetamol- and carbon tetrachloride-induced hepatotoxicity in rats

Treatment

AST

ALT

ALP

Group-I (normal saline)

18.07 ± 0.32

49.66 ± 0.08

39.87 ± 0.08

Group-II (paracetamol 750 mg/kg)

83.56 ± 0.34**

101.08 ± 0.08**

98.09 ± 0.11**

Group-III (100 mg/kg Silymarin)

24.09 ± 0.45***

55.76 ± 0.93***

44.10 ± 0.34**

Group-IV (200 mg/kg)

51.09 ± 0.13*

72.03 ± 0.13**

68.42 ± 0.29*

Group-V (300 mg/kg)

39.15 ± 0.54*

67.32 ± 0.09**

53.76 ± 0.03*

  1. AST: aspartate aminotransferase; ALT: alanine aminotransferase; ALP: alkaline phosphatase
  2. Values are expressed as mean ± SEM, n = 6 and were estimated using one-way ANOVA followed by post hoc Tukey HSD test. Comparisons are made between (1) Group-I versus Group-II, (2) Group-II versus Group-III, IV and V. *p ˂ 0.05, **p ˂ 0.01, ***p ˂ 0.001 considered as significant