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Table 4 Effects of ethanolic extract of L. rugosa on some liver function indices in paracetamol-induced hepatotoxic rats

From: Ameliorative effect of ethanolic extract of Limnophila rugosa (Scrophulariaceae) in paracetamol- and carbon tetrachloride-induced hepatotoxicity in rats

Treatment ALB DBL TBL Globulin TP TC
Group-I (normal saline) 48.09 ± 0.26 22.03 ± 0.34 19.54 ± 0.87 8.05 ± 0.34 56.72 ± 0.87 9.11 ± 0.42
Group-II (paracetamol 750 mg/kg) 19.65 ± 0.12** 47.23 ± 0.87** 59.98 ± 0.12** 5.11 ± 0.23** 18.09 ± 0.11** 19.65 ± 0.71**
Group-III (100 mg/kg Silymarin) 42.23 ± 0.78*** 24.11 ± 0.75*** 27.32 ± 0.90** 7.97 ± 0.54** 53.22 ± 0.87*** 8.23 ± 0.98***
Group-IV (200 mg/kg) 25.65 ± 0.87* 37.87 ± 0.05* 42.77 ± 0.55* 6.01 ± 0.76* 39.08 ± 0.45** 15.09 ± 0.04*
Group-V (300 mg/kg) 37.02 ± 0.82** 29.77 ± 0.32** 35.56 ± 0.11** 6.98 ± 0.09* 49.67 ± 0.34** 10.11 ± 0.98**
  1. ALB: albumin; DBL: direct bilirubin; TBL: total bilirubin; TP: total protein; TC: total cholesterol
  2. Values are expressed as mean ± SEM, n = 6 and were estimated using one-way ANOVA followed by post hoc Tukey HSD test. Comparisons are made between (1) Group-I versus Group-II, (2) Group-II versus Group-III, IV and V. *p ˂ 0.05,**p ˂ 0.01,***p ˂ 0.001 considered as significant