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Table 4 Effects of ethanolic extract of L. rugosa on some liver function indices in paracetamol-induced hepatotoxic rats

From: Ameliorative effect of ethanolic extract of Limnophila rugosa (Scrophulariaceae) in paracetamol- and carbon tetrachloride-induced hepatotoxicity in rats

Treatment

ALB

DBL

TBL

Globulin

TP

TC

Group-I (normal saline)

48.09 ± 0.26

22.03 ± 0.34

19.54 ± 0.87

8.05 ± 0.34

56.72 ± 0.87

9.11 ± 0.42

Group-II (paracetamol 750 mg/kg)

19.65 ± 0.12**

47.23 ± 0.87**

59.98 ± 0.12**

5.11 ± 0.23**

18.09 ± 0.11**

19.65 ± 0.71**

Group-III (100 mg/kg Silymarin)

42.23 ± 0.78***

24.11 ± 0.75***

27.32 ± 0.90**

7.97 ± 0.54**

53.22 ± 0.87***

8.23 ± 0.98***

Group-IV (200 mg/kg)

25.65 ± 0.87*

37.87 ± 0.05*

42.77 ± 0.55*

6.01 ± 0.76*

39.08 ± 0.45**

15.09 ± 0.04*

Group-V (300 mg/kg)

37.02 ± 0.82**

29.77 ± 0.32**

35.56 ± 0.11**

6.98 ± 0.09*

49.67 ± 0.34**

10.11 ± 0.98**

  1. ALB: albumin; DBL: direct bilirubin; TBL: total bilirubin; TP: total protein; TC: total cholesterol
  2. Values are expressed as mean ± SEM, n = 6 and were estimated using one-way ANOVA followed by post hoc Tukey HSD test. Comparisons are made between (1) Group-I versus Group-II, (2) Group-II versus Group-III, IV and V. *p ˂ 0.05,**p ˂ 0.01,***p ˂ 0.001 considered as significant