Ameliorative effect of ethanolic extract of Limnophila rugosa (Scrophulariaceae) in paracetamol- and carbon tetrachloride-induced hepatotoxicity in rats

Future Journal of Pharmaceutical Sciences

Table 5 Effect of ethanolic extract of L. rugosa on liver function enzymes in CCl₄-induced hepatotoxicity in rats

Treatment	AST	ALT	ALP
Group-I (normal saline)	22.47 ± 0.47	53.46 ± 0.88	44.07 ± 0.98
Group-II (CCl₄ 1.25 ml/kg)	103.62 ± 0.60**	133.63 ± 0.48**	177.06 ± 0.90**
Group-III (100 mg/kg silymarin)	36.46 ± 0.49**	62.85 ± 0.80***	49.17 ± 0.19**
Group-IV (200 mg/kg)	76.54 ± 0.70*	93.96 ± 0.80**	114.07 ± 1.20**
Group-V (300 mg/kg)	56.28 ± 0.82**	82.59 ± 0.57**	96.18 ± 0.93**

AST: aspartate aminotransferase; ALT: alanine aminotransferase; ALP: alkaline phosphatase
Values are expressed as mean ± SEM, n = 6 and were estimated using one-way ANOVA followed by post hoc Tukey HSD test. Comparisons are made between (1) Group-I versus Group-II, (2) Group-II versus Group-III, IV and V. *p ˂ 0.05, **p ˂ 0.01, ***p ˂ 0.001 considered as significant