Ameliorative effect of ethanolic extract of Limnophila rugosa (Scrophulariaceae) in paracetamol- and carbon tetrachloride-induced hepatotoxicity in rats

Future Journal of Pharmaceutical Sciences

Table 6 Effects of ethanolic extract of L. rugosa on some liver function indices of CCl₄-induced hepatotoxic rats

Treatment	ALB	DBL	TBL	Globulin	TP	TC
Group-I (normal saline)	56.59 ± 1.06	16.71 ± 0.42	15.60 ± 0.56	6.66 ± 0.24	60.03 ± 0.52	6.81 ± 0.35
Group-II (CCl₄ 1.25 ml/kg)	14.80 ± 0.23**	67.18 ± 0.16**	76.58 ± 0.41**	3.72 ± 0.09**	16.43 ± 0.41**	21.34 ± 0.65**
Group-III (100 mg/kg Silymarin)	45.62 ± 0.69***	28.09 ± 0.67***	22.76 ± 0.64**	5.64 ± 0.29*	54.46 ± 1.29***	9.05 ± 0.20***
Group-IV (200 mg/kg)	29.16 ± 0.62*	49.21 ± 0.79*	56.30 ± 1.40**	4.86 ± 0.54^ns	35.88 ± 1.07**	17.57 ± 0.26**
Group-V (300 mg/kg)	39.32 ± 0.52**	37.62 ± 0.58**	37.43 ± 1.16**	4.53 ± 0.24^ns	45.87 ± 0.58**	11.20 ± 0.12**

ALB: albumin; DBL: direct bilirubin; TBL: total bilirubin; TP: total protein; TC: total cholesterol
Values are expressed as mean ± SEM, n = 6 and were estimated using one-way ANOVA followed by post hoc Tukey HSD test. Comparisons are made between (1) Group-I versus Group-II, (2) Group-II versus Group-III, IV and V. ns: nonsignificant, *p ˂ 0.05, **p ˂ 0.01, ***p ˂ 0.001 considered as significant