Table 1 Examples of FDA-approved nanomedicines
From: Pharmaceutical nanotechnology: from the bench to the market
Trade name | Material description | Advantages | Indications | Approval year |
|---|---|---|---|---|
Estrasorbâ„¢ | Micellar Estradiol | Controlled delivery of the drug | Menopausal therapy | 2003 |
Marqibo® | Liposomal Vincristine | Increased delivery to tumor tissue; decreased systemic toxicity resulting from side-effects | Acute lymphoblastic leukemia | 2012 |
Onivyde® | Liposomal Irinotecan | Pancreatic cancer | 2015 | |
BNT162b2 vaccine (developed by BioNTech and Pfizer) | Nucleoside modified mRNA encoding the viral spike glycoprotein of SARS-CoV-2, encapsulated in lipid nanoparticles | Protection of the non-replicating RNA from degradation and allow it to be delivered into host cells after intramuscular injection | Prevention of coronavirus disease | 2020 |
mRNA-1273Â vaccine (developed by Moderna) | Lipid nanoparticle-encapsulated mRNA-based vaccine, which encodes the spike protein (S protein) of SARS-CoV-2 | Lipid nanoparticles are playing a key role in protecting and transporting the mRNA effectively to the right place in cells | Prevention of coronavirus disease | 2020 |