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Table 7 System precision data at LOQ

From: Quantification of organic volatile impurities in Oseltamivir phosphate drug substances by head space gas chromatography

No of injections Peak areas
Methanol Ethanol Acetonitrile IPA DCM MTBE Ethyl acetate
1 9.9 4.35 13.44 4.64 3.43 4.73 4.76
2 11.13 3.53 14.29 5.74 4.06 4.62 4.54
3 10.78 3.49 13.71 5.51 3.76 4.58 4.94
4 10.29 3.93 13.7 5.11 3.21 4.46 4.24
5 10.03 3.37 13.32 6.13 3.15 5.01 4.47
6 10.84 3.55 15.14 5.06 3.49 4.79 4.27
Avg 10.5 3.7 13.9 5.4 3.5 4.7 4.5
STDEV 0.493 0.369 0.679 0.535 0.344 0.192 0.274
%RSD 4.7 10 4.9 9.9 9.8 4.1 6.1
No of injections Peak areas
THF 1,4-Dioxane DMF Toluene Hexanes
1 3.92 3.22 2.5 2.81 5.08
2 3.75 2.89 2.42 2.77 5.87
3 3.71 2.85 2.55 2.53 5.84
4 3.67 2.9 1.87 2.75 4.78
5 3.59 2.67 2.25 2.47 4.91
6 3.46 2.97 2.31 2.42 4.82
Avg 3.7 2.9 2.3 2.6 5.2
STDEV 0.155 0.18 0.246 0.171 0.505
%RSD 4.2 6.2 10.7 6.6 9.7
  1. Bold values indicate better results than other filtering methods