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Future Journal of Pharmaceutical Sciences

Table 8 Robustness data

From: Quantification of organic volatile impurities in Oseltamivir phosphate drug substances by head space gas chromatography

Name of organic volatile impurity

%RSD for different method parameters

Column oven Temp. 35 °C

Column oven Temp. 45 °C

Injector temp. 175 °C

Injector temp. 185 °C

Methanol

2.0

2.2

1.3

1.1

Ethanol

2.6

1.8

1.3

0.4

Acetonitrile

2.1

1.9

1.1

0.6

IPA

2.6

2.1

1

0.5

DCM

2.0

1.4

1

0.9

MTBE

1.0

0.7

1.7

1

Ethyl acetate

1.6

1.1

0.7

0.6

THF

1.4

0.8

0.8

0.6

1,4-Dioxane

3.9

2.7

1.9

1.1

DMF

13.5

10.3

5

5.2

Toluene

3.9

2.5

1.2

0.7

Hexanes

0.9

0.7

3.4

1.4

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