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Table 8 Robustness data

From: Quantification of organic volatile impurities in Oseltamivir phosphate drug substances by head space gas chromatography

Name of organic volatile impurity %RSD for different method parameters
Column oven Temp. 35 °C Column oven Temp. 45 °C Injector temp. 175 °C Injector temp. 185 °C
Methanol 2.0 2.2 1.3 1.1
Ethanol 2.6 1.8 1.3 0.4
Acetonitrile 2.1 1.9 1.1 0.6
IPA 2.6 2.1 1 0.5
DCM 2.0 1.4 1 0.9
MTBE 1.0 0.7 1.7 1
Ethyl acetate 1.6 1.1 0.7 0.6
THF 1.4 0.8 0.8 0.6
1,4-Dioxane 3.9 2.7 1.9 1.1
DMF 13.5 10.3 5 5.2
Toluene 3.9 2.5 1.2 0.7
Hexanes 0.9 0.7 3.4 1.4