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Table 2 Extraction recovery results for ELX and RFX

From: Validation of the HPLC–PDA method for detection of eluxadoline and rifaximin in rat plasma and application in a pharmacokinetic study

Analytes

Spiked conc.level (ng mL−1)

Area response (n = 6)

Extraction recovery (%)

CV (%)

Extracted mean response

Post extracted mean response

ELX

LQC (50.0)

65,540

67,563

97.0

0.68

MQC (100.0)

130,424

142,522

91.5

0.16

HQC (150.0)

195,784

208,552

93.8

0.31

RFX

LQC (100.0)

120,553

122,549

98.3

0.17

MQC (200.0)

240,481

262,371

91.6

0.13

HQC (300.0)

362,942

380,569

95.3

0.83