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Table 3 Matrix effect results for ELX and RFX

From: Validation of the HPLC–PDA method for detection of eluxadoline and rifaximin in rat plasma and application in a pharmacokinetic study

Analytes

Area response (n = 6)

Matrix factor

CV (%)

Post extracted mean response

Neat mean response

LQC

HQC

LQC

HQC

LQC

HQC

LQC

HQC

ELX

65,540

195,784

67,563

208,552

0.97

0.93

0.68

0.32

RFX

120,553

362,942

122,549

380,569

0.98

0.95

0.18

0.83