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Table 5 Pharmacokinetic parameters

From: Validation of the HPLC–PDA method for detection of eluxadoline and rifaximin in rat plasma and application in a pharmacokinetic study

Parameter

Analytes

RFX

ELX

t1/2 (h)

5.0

5.0

tmax (h)

1.5

1.5

cmax (ng/mL)

95.2

179.3

AUC0-t (ng h/mL)

245

463

AUC0-∞ (ng h/mL)

245

463

AUCt-∞ (ng h/mL)

11.9

23.8