Uncovering the biodiversity and biosynthetic potentials of rare actinomycetes

Ezeobiora, Chijioke E.; Igbokwe, Nwamaka H.; Amin, Dina H.; Enwuru, Nkechi V.; Okpalanwa, Chiamaka F.; Mendie, Udoma E.

doi:10.1186/s43094-022-00410-y

Future Journal of Pharmaceutical Sciences

Table 2 Rare actinomycetes with their bioactive compounds

From: Uncovering the biodiversity and biosynthetic potentials of rare actinomycetes

S/N	Bioactive compound	Chemical class	Source organism	Activity	Reference
1	Taromycin A	Lipopeptide	Saccharomonospora sp.	Anti-MDR pathogen	[147]
2	Retimycin A	Quinomycin-peptide	Salinispora sp	Cytotoxic	[148]
3	Sioxanthin	Carotenoid	Salinispora sp	Iron chelating	[149]
4	Lobosamide A-C	Polyene compound	Micromonospora sp	Anti-protozoan	[150]
5	Tetrocarcin N & O	Glycosides	Micromonospora sp.	Antibacterial	[151]
6	Nenestatin A	Benzofluorene	Micromonospora echinospora	Antibacterial	[152]
7	Thiasporines A-C	Thiazine	Actinomycetospora chlora	Cytotoxic	[153]
8	1,4-Dioxane	Dioxane	Micromonospora sp	Antibacterial	[154]
9	α-Pyrones 1–8	Pyrones	Nocardiopsis sp	Antibacterial	[154]
10	Glycerol 1-hydroxy-2,5-dimethyl benzoate	Salicylic derivative	Verrucosispora sp	Anti-MRSA	[155]
11	Nocapyrones O-S	α-Pyrones	Nocardiopsis sp	Cytotoxicity	[155]
12	Nocazine F	Piperazine	Nocardiopsis sp	Cytotoxicity	[155]
13	Bramycin B	Macrolide	Pseudonocardia carboxydivorans	Antibacterial	[155]
14	Cyanogranide	Alkaloid	Actinoalloteichus cyanogriseus	MDR-reversing	[153]
15	Actinosporin A	O-glycosylated angucyclines	Actinokineospora sp	Anti-trypanosomal	[156]
16	Solwaric acids A & B	Aromatic acids	Solwaraspora sp	Antibacterial	[156]
17	Seriniquinone	Quinones	Serinicoccus sp	Anticancer	[156]
18	Farozoline A	Polyketide	Actinomadura sp	Anti-candida	[156]
19	Amycolactam	Indole alkaloid	Amycolatopsis sp	Cytotoxic	[153]
20	Dermacozines H	Phenazine	Dermacoccus abyssi	Antioxidant	[156]
21	Microbacterins A & B	Peptaibols	Microbacterium sediminis	Cytotoxic	[154]
22	Salinipostins A-K	Phosphotriester	Salinospora sp	Anti-malaria	[154]
23	Saccharothrixones A-D	Aromatic polyketides	Saccharothrix sp	Cytotoxic	[154]
24	Telavancin	Glycopeptide	Amycolatopsis orientalis	Antimicrobial	[157]
25	Fidaxomicin	Tiacumicin	Dactylosporangium aurantiacum	Antimicrobial	[157]
26	Salinosporamide A	ß-lactone-γ-lactam	Salinispora tropica	Anticancer	[158]
27	Arenamide A &B	Peptide	Salinispora sp	Anti-inflammatory	[159]
28	Anthracimycin	Polyketide	Streptomyces sp	Anti- anthrax	[160]
29	Halomadurone A	Pyrones	Actinomadura sp	Anti-proliferative	[156]
30	Levantilide C	Macrolides	Micromonospora sp	Anti-proliferative	[156]
31	Nocardiamide A, B	Hexapeptide	Nicardiopsis sp	Antimicrobial	[153]
32	Telithromycin	Macrolide	Saccharopolyspora erythraea	Antimicrobial	[157]
33	Biapenem	Carbapenem	Streptomyces cattleya	Antimicrobial	[157]
34	Ertapenem	Carbapenem	Streptomyces cattleya	Antibacterial	[157]
35	Daptomycin	Lipopeptide	Streptomyces roseosporus	Antibacterial	[157]
36	Tigecycline	Tetracycline	Streptomyces aureofaciens	Antimicrobial	[157]
37	Dalbavancin	Glycopeptide	Nonomuria sp	Antimicrobial	[157]
38	Oritavancin	Gycopeptide	Amycolatopsis orientalis	Antimicrobial	[157]
39	Tazobactam	ß-lactamase inhibitor	Actinomycete sp	Antimicrobial	[157]

Back to article page