Table 1 Formulation of OXC microparticles using face-centred central composite design
S. no | Formulation code | Drug | Level (Concentration of sodium alginate) | Carbopol 971P:sodium alginate ratio | Level stirring speed | Stirring speed (RPM) |
|---|---|---|---|---|---|---|
1 | B1 | 1 | 0 | 1:1.5 | + 1 | 1041 |
2 | B2 | 1 | + 1 | 1:2.21 | − 1 | 758 |
3 | B3 | 1 | 0 | 1:1.5 | 0 | 900 |
4 | B4 | 1 | + 1 | 1:2.21 | 0 | 900 |
5 | B5 | 1 | + 1 | 1:2.21 | + 1 | 1041 |
6 | B6 | 1 | 0 | 1:1.5 | 0 | 900 |
7 | B7 | 1 | 0 | 1:1.5 | − 1 | 758 |
8 | B8 | 1 | 0 | 1:1.5 | 0 | 900 |
9 | B9 | 1 | − 1 | 1:0.793 | 0 | 900 |
10 | B10 | 1 | 0 | 1:1.5 | 0 | 900 |
11 | B11 | 1 | 0 | 1:1.5 | 0 | 900 |
12 | B12 | 1 | − 1 | 1:0.793 | + 1 | 1041 |
13 | B13 | 1 | − 1 | 1:0.793 | − 1 | 758 |