Formulation of oxybutynin chloride microparticle-loaded suppositories: in vitro characterization and in vivo pharmacokinetic study

Future Journal of Pharmaceutical Sciences

Table 2 Results of oxybutynin chloride Microparticles formulated using face-centred central composite design

S. no	Formulation code	Production yield (%)	Entrapment efficiency (%)	Mucoadhesion strength (%)	Drug loading (%)
1	B1	93.70 ± 3.67	91.80 ± 3.92	88 ± 3.26	23.19 ± 0.54
2	B2	92.90 ± 4.26	95.98 ± 4.44	96 ± 1.88	24.62 ± 0.45
3	B3	89.93 ± 3.78	89.65 ± 6.68	89.33 ± 4.98	22.79 ± 0.37
4	B4	94.75 ± 4.21	96.36 ± 6.90	92 ± 3.26	23.00 ± 0.54
5	B5	87.82 ± 5.01	95. 28 ± 4.02	92 ± 1.88	23.23 ± 0.45
6	B6	90.02 ± 2.98	89.04 ± 3.94	90.67 ± 1.88	21.82 ± 0.40
7	B7	88.39 ± 3.98	92.15 ± 4.92	89.67 ± 3.26	23.65 ± 0.58
8	B8	90.25 ± 4.34	89.36 ± 6.24	92 ± 1.88	23.19 ± 0.54
9	B9	84. 54 ± 3.87	78.53 ± 4.92	85.33 ± 3.77	22.59 ± 0.34
10	B10	89.90 ± 4.22	90.92 ± 4.68	89.67 ± 1.88	21.79 ± 0.37
11	B11	90.41 ± 4.78	89.69 ± 4.36	89.33 ± 4.98	22.84 ± 0.51
12	B12	79.55 ± 3.66	84.68 ± 2.48	86.66 ± 1.88	22.43 ± 0.25
13	B13	86.30 ± 4.44	87.15 ± 3.36	85.33 ± 3.77	22.29 ± 0.35

B₂ is the optimized batch based on Numerical optimization that is further evaluated for different parameters as well as to develop microparticle loaded suppository