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Future Journal of Pharmaceutical Sciences

Table 3 Pharmacokinetic parameters of oral and rectally administered OXC formulations (n = 5)

From: Formulation of oxybutynin chloride microparticle-loaded suppositories: in vitro characterization and in vivo pharmacokinetic study

Parameters

OXC oral suspension

OXC loaded suppository

OXC microparticles loaded suppository

Cmax (ng/mL)

1.911 ± 0.34

2.546 ± 0.89

3.472 ± 0.45

Tmax (h)

2

3

3

AUCtotal (ng h/mL)

21.34 ± 7.20

25.47 ± 5.674

38.58 ± 6.879

AUC0–∞ (ng h/mL)

22.62 ± 4.32

25.87 ± 5.16

44.94 ± 6.43

Frel (%)

–

–

173.72

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