Nanostructured lipid carriers: a promising drug carrier for targeting brain tumours

Garg, Jivesh; Pathania, Khushboo; Sah, Sangeeta Pilkhwal; Pawar, Sandip V.

doi:10.1186/s43094-022-00414-8

Future Journal of Pharmaceutical Sciences

Table 2 Example of the various drug-loaded NLCs prepared by different research groups using different methods in the last 6 years (2016–2021)

From: Nanostructured lipid carriers: a promising drug carrier for targeting brain tumours

S. No.	Method of preparation	Drug loaded	Particle size (nm)	References
1	Hot homogenization/hot homogenization–ultrasonication method	Simvastatin	125.4 ± 2.66	[103]
		Ciprofloxacin	193.1 ± 5.1	[104]
		Methotrexate	278 ± 10	[105]
		Vitamin D₃	77–2504	[106]
		Docosahexaenoic acid	211	[107]
		Epigallocatechin gallate	85	[108]
		Cinnamon essential oil	99.98–119.4	[109]
		L-ascorbic acid and Gold Tri.E 30	139.9–277.1	[110]
		Zotepine	145.8 ± 2.5	[111]
		Doxorubicin and β-elemene	190	[112]
		Itraconazole	147.31 ± 1.43	[113]
		Isotretinoin	154.1	[114]
		Fentanyl citrate	90	[115, 116]
		Econazole nitrate	134.8–182.73	[117]
		Pyrazinamide	200–230	[118]
		Progesterone	179	[119]
		Melatonin	119	[120]
		Dithranol	< 300	[121]
		Isoliquiritigenin	150.19–251.69	[122]
2	Cold homogenization method	Ondansetron hydrochloride	206–280	[123]
		Propranolol hydrochloride	385–880	[124]
		Apremilast	758	[125]
		Carvedilol	308.3–477.1	[126]
		Spironolactone or progesterone	225.92 ± 0.41–447.80 ± 0.66	[127]
3	Solvent emulsification evaporation method	Doxorubicin	134.0 ± 2.3	[128, 129]
		Tacrolimus	400 ± 6.08 nm -1 ± 4.93 µm	[130]
		Salvia off. Extract	149.1 ± 7.25	[131]
		Docetaxel	240.83 ± 3.44	[132, 133]
		Vincristine suphate	187 ± 3.52	[134]
4	Solvent emulsification diffusion method	Rivastigmine	201–458	[135]
		Resveratrol	155.08 ± 3.28	[136]
		Adefovir dipivoxil	240.2 ± 2.5	[137]
		Cyproterone acetate	100, 300 and 600	[138]
		Temozolomide	153.5 ± 1.9	[139]
		Olanzapine	158.5	[140]
5	Solvent injection method	Etoposide and curcumin	114	[141]
		Temazepam	306.6 ± 49.6	[142]
		Ondansetron hydrochloride	185.2 ± 1.9	[143]
		Resveratrol	88.3 ± 3.1	[144]
		Alendronate	186.1 ± 2.8	[145]
		Rivastigmine	123.2 ± 2.3	[146]
		Etoposide	82.16 ± 2.87	[147]
6	Microemulsion/microemulsion–sonication method	Aceclofenac	230	[148]
		Olmesartan medoxomil	250	[149]
		Voriconazole	250.2 ± 03.1	[150]
		Triamcinolone acetonide	112.27–227.18	[151]
		Miltefosine	143 ± 16	[152]
		Curcumin	225.8 ± 2.3	[153]
		Vorinostat	150	[154]
		Mefenamic acid	160–310	[155]
		Carvacrol	98.42 ± 0.80	[156]
		Docetaxel	150–180	[157]
		Piroxicam	< 300	[158, 159]
		Mometasone furoate	163.2 ± 0.522	[160]
7	Double emulsion–solvent evaporation/double emulsion–solvent diffusion method	Ceftriaxone	86	[161]
		Ficus deltoidea extract	155.9 ± 7.11	[162]
		5-fluorouracil	232.4 ± 2.20 and 228.0 ± 1.85	[163]
		Epidermal growth factor and curcumin	331.8	[164]
		Baclofen	127 ± 10 – 253 ± 5	[165]
		Chloroquine phosphate	66.50 ± 1.21	[166]
8	Phase inversion temperature method	Vitamin D₃	15.69 ± 1.45 nm–58.16 ± 2.41	[167]
		Metronidazole	276.1 ± 4.36	[168]
		Idebenone and tocopheryl acetate	26.76 ± 0.33	[169]
		Ferulic acid and Lavandula essential oil	< 150	[170]
		Fluconazole	158.33 ± 2.55	[171]
		Astrocaryummurumuru butter	33.4 ± 0.81–33.7 ± 1.15	[172]
9	Supercritical fluid method	Trans-resveratrol	180–190	[173]
10	Hot-melt extrusion method	Itraconazole	101.20 ± 1.69	[174]
		Lidocaine	< 50	[100]
		Ginsenoside	150–200	[175]
		Celecoxib	250.9	[176]
		Peppermint essential oil	40–250	[177]

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