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Table 2 The effect of HFHF alone or in combination with silymarin, curcumin, and celery on serum liver enzymes, glycemic profile, lipid profile, and hepatic MDA and GSH

From: The ameliorative effect of Apium graveolens & curcumin against Non-alcoholic fatty liver disease induced by high fructose-high fat diet in rats

 

Parameters

Control

HFHF

HFHF + Sily

HFHF + Cur

HFHF + Celery

Liver enzymes

GPT U/L

25.67 ± 1.27

59.32 ± 2.94a

40.17 ± 1.23ab

46.67 ± 1.23ab

41.17 ± 2.4abc

GOT U/L

47.17 ± 1.7

78.01 ± 2.1a

55.50 ± 1.12b

56.67 ± 1.4ab

49.00 ± 1.2bc

Glycemic profile

FBG mg/dl

67.13 ± 2.1

176.5 ± 2.7a

152.5 ± 2.3a

85.41 ± 1.2b

72.5 ± 1.3b

FBI Um/ml

10.5 ± 0.7

7.8 ± 0.2a

9.5 ± 0.4ab

11.8 ± 0.6ab

10.9 ± 0.5b

HOMA-IR

1.74 ± 0.02

3.38 ± 0.04a

2.4 ± 0.02ab

2.28 ± 0.05ab

2.11 ± 0.07ab

Lipid profile

S.CH mg/dl

163.17 ± 1.6

227.18 ± 2.4a

194.88 ± 1.7ab

184.88 ± 1.04ab

168.45 ± 1.4bc

S.TG mg/dl

53.50 ± 2.72

152.12 ± 1.1a

125.23 ± 1.23ab

64.44 ± 1.7ab

59.4 ± 2.1b

HDL mg/dl

28.5 ± 0.20

17.8 ± 0.11a

18.9 ± 0.14a

24.5 ± 0.15ab

29.12 ± 017bc

Oxidative stress

MDA µmol/g.wet.tissue

1.47 ± 0.04

2.01 ± 0.1a

1.71 ± 0.03ab

1.68 ± 0.07b

1.57 ± 0.06b

GSH µmol/g.wet.tissue

25.7 ± 0.24

14.47 ± 0.1a

18.44 ± 0.09ab

19.71 ± 0.08ab

21.22 ± 0.12ab

  1. Data represented by mean ± SE
  2. ɑp significant difference from control at P < 0.05
  3. bp significant difference from HFHF at P < 0.05
  4. cp significant difference between HFHF + Cur and HFHF + Celery groups at P < 0.05