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Table 2 The effect of HFHF alone or in combination with silymarin, curcumin, and celery on serum liver enzymes, glycemic profile, lipid profile, and hepatic MDA and GSH

From: The ameliorative effect of Apium graveolens & curcumin against Non-alcoholic fatty liver disease induced by high fructose-high fat diet in rats

  Parameters Control HFHF HFHF + Sily HFHF + Cur HFHF + Celery
Liver enzymes GPT U/L 25.67 ± 1.27 59.32 ± 2.94a 40.17 ± 1.23ab 46.67 ± 1.23ab 41.17 ± 2.4abc
GOT U/L 47.17 ± 1.7 78.01 ± 2.1a 55.50 ± 1.12b 56.67 ± 1.4ab 49.00 ± 1.2bc
Glycemic profile FBG mg/dl 67.13 ± 2.1 176.5 ± 2.7a 152.5 ± 2.3a 85.41 ± 1.2b 72.5 ± 1.3b
FBI Um/ml 10.5 ± 0.7 7.8 ± 0.2a 9.5 ± 0.4ab 11.8 ± 0.6ab 10.9 ± 0.5b
HOMA-IR 1.74 ± 0.02 3.38 ± 0.04a 2.4 ± 0.02ab 2.28 ± 0.05ab 2.11 ± 0.07ab
Lipid profile S.CH mg/dl 163.17 ± 1.6 227.18 ± 2.4a 194.88 ± 1.7ab 184.88 ± 1.04ab 168.45 ± 1.4bc
S.TG mg/dl 53.50 ± 2.72 152.12 ± 1.1a 125.23 ± 1.23ab 64.44 ± 1.7ab 59.4 ± 2.1b
HDL mg/dl 28.5 ± 0.20 17.8 ± 0.11a 18.9 ± 0.14a 24.5 ± 0.15ab 29.12 ± 017bc
Oxidative stress MDA µmol/g.wet.tissue 1.47 ± 0.04 2.01 ± 0.1a 1.71 ± 0.03ab 1.68 ± 0.07b 1.57 ± 0.06b
GSH µmol/g.wet.tissue 25.7 ± 0.24 14.47 ± 0.1a 18.44 ± 0.09ab 19.71 ± 0.08ab 21.22 ± 0.12ab
  1. Data represented by mean ± SE
  2. ɑp significant difference from control at P < 0.05
  3. bp significant difference from HFHF at P < 0.05
  4. cp significant difference between HFHF + Cur and HFHF + Celery groups at P < 0.05