Table 1 Composition and physicochemical properties of different MEL-loaded ME
Formula code | Percentage ratio (%w/w) | Droplet size (nm) ± SD | PDI ± SD | ZP (mV) ± SD | ||||
|---|---|---|---|---|---|---|---|---|
Smix ratio | Oil wt% | Tween 80 | PEG400 | Water % | ||||
TPA1 | 1:1 | 3.3 | 15 | 15 | 66.6 | 55 ± 0.30 | 0.3 ± 0.01 |  − 1.0 ± 0.01 |
TPA2 | 1:1 | 6.6 | 13.3 | 13.3 | 66.6 | 66 ± 0.10 | 0.2 ± 0.03 | 0.1 ± 0.01 |
TPA3 | 1:1 | 10 | 11.6 | 11.6 | 66.6 | 68 ± 0.50 | 0.3 ± 0.05 | 0.2 ± 0.01 |
TPA4 | 1:1 | 13.3 | 10 | 10 | 66.6 | 98 ± 0.60 | 0.3 ± 0.03 |  − 1.0 ± 0.01 |
TPA5 | 1:1 | 16.6 | 8.3 | 8.3 | 66.6 | 88 ± 0.20 | 0.1 ± 0.06 |  − 0.1 ± 0.01 |
TPA6 | 1:1 | 20 | 6.6 | 6.6 | 66.6 | 67 ± 0.40 | 0.3 ± 0.05 |  − 1.0 ± 0.01 |
TPA7 | 1:1 | 23.3 | 5 | 5 | 66.6 | 61 ± 0.10 | 0.1 ± 0.01 |  − 1.0 ± 0.01 |
TPB1 | 2:1 | 3.3 | 20 | 10 | 66.6 | 44 ± 0.10 | 0.3 ± 0.01 | 0.5 ± 0.01 |
TPB2 | 2:1 | 6.6 | 17.7 | 8.8 | 66.6 | 45 ± 0.20 | 0.3 ± 0.03 | 0.1 ± 0.01 |
TPB3 | 2:1 | 10 | 15.5 | 7.7 | 66.6 | 54 ± 0.70 | 0.3 ± 0.04 | 0.1 ± 0.01 |
TPB4 | 2:1 | 13.3 | 13.3 | 6.6 | 66.6 | 57 ± 0.60 | 0.2 ± 0.03 | 0.5 ± 0.01 |
TPB5 | 2:1 | 16.6 | 11.0 | 5.5 | 66.6 | 69 ± 0.20 | 0.1 ± 0.04 |  − 0.1 ± 0.01 |
TPB6 | 2:1 | 20 | 8.8 | 4.4 | 66.6 | 60 ± 0.60 | 0.3 ± 0.05 | 1.0 ± 0.01 |
TPB7 | 2:1 | 23.3 | 6.6 | 3.3 | 66.6 | 56 ± 0.10 | 0.1 ± 0.01 |  − 0.1 ± 0.01 |
TPC1 | 3:1 | 3.3 | 22.5 | 7.5 | 66.6 | 30 ± 0.20 | 0.3 ± 0.01 |  − 1.0 ± 0.01 |
TPC2 | 3:1 | 6.6 | 19.9 | 6.6 | 66.6 | 39 ± 0.01 | 0.3 ± 0.03 |  − 1.0 ± 0.04 |
TPC3 | 3:1 | 10 | 17.5 | 5.8 | 66.6 | 44 ± 0.50 | 0.3 ± 0.04 |  − 1.0 ± 0.01 |
TPC4 | 3:1 | 13.3 | 15 | 5 | 66.6 | 49 ± 0.30 | 0.2 ± 0.03 |  − 0.9 ± 0.05 |
TPC5 | 3:1 | 16.6 | 12.4 | 4.1 | 66.6 | 84 ± 0.20 | 0.1 ± 0.04 |  − 1.0 ± 0.01 |
TPC6 | 3:1 | 20 | 9.9 | 3.3 | 66.6 | 69 ± 0.20 | 0.2 ± 0.05 |  − 1.0 ± 0.02 |
TPC7 | 3:1 | 23.3 | 7.5 | 2.5 | 66.6 | 63 ± 0.10 | 0.1 ± 0.01 |  − 1.0 ± 0.01 |
TPD1 | 4:1 | 3.3 | 24 | 6 | 66.6 | 31 ± 0.20 | 0.2 ± 0.01 |  − 0.6 ± 0.01 |
TPD2 | 4:1 | 6.6 | 21.3 | 5.3 | 66.6 | 32 ± 0.01 | 0.2 ± 0.03 |  − 0.8 ± 0.04 |
TPD3 | 4:1 | 10 | 18.6 | 4.6 | 66.6 | 38 ± 0.50 | 0.3 ± 0.02 |  − 0.1 ± 0.01 |
TPD4 | 4:1 | 13.3 | 16 | 4 | 66.6 | 39 ± 0.30 | 0.3 ± 0.03 |  − 0.5 ± 0.05 |
TPD5 | 4:1 | 16.6 | 13.2 | 3.3 | 66.6 | 41 ± 0.20 | 0.1 ± 0.01 |  − 0.9 ± 0.01 |
TPD6 | 4:1 | 20 | 10.6 | 2.6 | 66.6 | 37 ± 0.20 | 0.2 ± 0.05 |  − 0.5 ± 0.02 |
TPD7 | 4:1 | 23.3 | 8 | 2 | 66.6 | 30 ± 0.10 | 0.1 ± 0.02 |  − 0.5 ± 0.01 |