Batch | Drug (mg) | CS (mg) | MPS (nm) | ZP (mV) | Charge | PDI | % Yield | % EE | % DR8 | % DR12 |
---|---|---|---|---|---|---|---|---|---|---|
F1 | 0 | 100 | 239.3 ± 1.8 | 35.0 ± 1.2 | strongly cationic | 0.181 ± 0.010 | 56 | 0 | − | − |
F2 | 100 | 50 | 248.6 ± 1.4 | 32.5 ± 1.4 | strongly cationic | 0.191 ± 0.012 | 60 | 17.00 ± 2.0 | 92.15 ± 2.04 | 98.94 ± 2.49 |
F3 | 100 | 100 | 440.8 ± 3.9 | 36.3 ± 0.8 | strongly cationic | 0.121 ± 0.062 | 55.5 | 23.76 ± 1.8 | 86.53 ± 3.04 | 95.25 ± 2.89 |
F4 | 100 | 150 | 549.1 ± 0.3 | 37.7 ± 1.4 | strongly cationic | 0.205 ± 0.023 | 56.33 | 34.98 ± 4.7 | 84.21 ± 2.53 | 92.34 ± 2.49 |
F5 | 100 | 200 | 687.8 ± 4.3 | 34.4 ± 1.8 | strongly cationic | 0.240 ± 0.030 | 51.33 | 39.60 ± 4.0 | 82.43 ± 1.49 | 90.21 ± 1.35 |
F6 | 100 | 250 | 803.4 ± 2.6 | 35.7 ± 0.5 | strongly cationic | 0.344 ± 0.024 | 59.33 | 61.20 ± 7.0 | 81.67 ± 1.36 | 87.66 ± 1.36 |
F7 | 100 | 300 | 928.7 ± 4.6 | 38.9 ± 1.0 | strongly cationic | 0.481 ± 0.022 | 54.33 | 60.48 ± 4.3 | 79.78 ± 2.47 | 85.36 ± 2.16 |