Evaluation parameter | Time period for sampling | |||
---|---|---|---|---|
Initial | After 1Â month | After 3Â months | After 6Â months | |
Particle size (nm) | 440.8 ± 3.9 | 459.3 ± 3.8 | 459.3 ± 3.8 | 459.3 ± 3.8 |
Zeta potential (mV) | 36.3 ± 0.8 | 37.7 ± 1.13 | 36.78 ± 2.01 | 40.4 ± 2.51 |
% Entrapment efficiency | 32.76 ± 1.8 | 33.11 ± 1.39 | 34.26 ± 1.69 | 31.6 ± 1.28 |
PDI | 0.121 ± 0.032 | 0.129 ± 0.052 | 0.123 ± 0.041 | 0.137 ± 0.071 |
% drug release at 8 h | 86.53 ± 3.45 | 85.83 ± 1.87 | 89.32 ± 2.14 | 87.96 ± 2.01 |
% drug release at 12 h | 95.25 ± 2.84 | 94.89 ± 1.66 | 94.67 ± 2.16 | 96.19 ± 1.86 |