Table 2 Toxicity prediction for all experimental molecules (from T1 to T8) using Rat Acute Toxicity GUSAR model
Route of administration | LD50 mg/kg | |||||||
|---|---|---|---|---|---|---|---|---|
T1 | T2 | T3 | T4 | T5 | T6 | T7 | T8 | |
Intraperitoneal | 656,000 | 637,800 | 623,400 | 634,100 | 634,100 | 654,000 | 610,000 | 517,200 |
Intravenous | 215,400 | 223,400 | 165,900 | 187,900 | 187,900 | 234,000 | 94,310 | 207,500 |
Oral | 3,081,000 | 3,134,000 | 2,921,000 | 2,756,000 | 2,756,000 | 3,204,000 | 1,082,000 | 2,610,000 |
Subcutaneous | 3,824,000 | 3,735,000 | 4,182,000 | 2,797,000 | 2,797,000 | 3,505,000 | 4,338,000 | 2,383,000 |