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Table 10 Robustness study

From: Experimental design approach, screening and optimization of system variables, analytical method development of flurbiprofen in nanoparticles and stability-indicating methods for high-pressure liquid chromatography

Change flow

FLOW RATE-1.0

   

FLOW RATE-1.2

 

Sr No

Conc µg/ml

Area

Sr No

Conc µg/ml

Area

1

50

3943.83

1

50

3276.56

2

50

3941.49

2

50

3281.77

 

Mean

3942.66

 

Mean

3279.17

 

SD

1.65

 

SD

3.68

 

%RSD

0.04

 

%RSD

0.11

Mobile phase

 

81.5 + 18.5%OPA

Mobile phase

83.5 + 16.5%OPA

 

Sr No

Conc µg/ml

Area

Sr No

Conc. µg/ml

Area

1

50

3581.69

1

50

3583.77

2

50

3585.11

2

50

3586.84

 

Mean

3583.4

 

Mean

3585.31

 

SD

2.42

 

SD

2.17

 

%RSD

0.07

 

%RSD

0.06

Wavelength Change

 

246 nm

 

248 nm

 

Sr No

Conc. µg/ml

Area

Sr No

Conc. µg/ml

Area

1

50

3568.71

1

50

3530.68

2

50

3569.6

2

50

3531.29

 

Mean

3569.2

 

Mean

3531.0

 

SD

0.63

 

SD

0.43

 

%RSD

0.02

 

%RSD

0.01