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Table 10 Robustness study

From: Experimental design approach, screening and optimization of system variables, analytical method development of flurbiprofen in nanoparticles and stability-indicating methods for high-pressure liquid chromatography

Change flow
FLOW RATE-1.0     FLOW RATE-1.2  
Sr No Conc µg/ml Area Sr No Conc µg/ml Area
1 50 3943.83 1 50 3276.56
2 50 3941.49 2 50 3281.77
  Mean 3942.66   Mean 3279.17
  SD 1.65   SD 3.68
  %RSD 0.04   %RSD 0.11
Mobile phase   81.5 + 18.5%OPA Mobile phase 83.5 + 16.5%OPA  
Sr No Conc µg/ml Area Sr No Conc. µg/ml Area
1 50 3581.69 1 50 3583.77
2 50 3585.11 2 50 3586.84
  Mean 3583.4   Mean 3585.31
  SD 2.42   SD 2.17
  %RSD 0.07   %RSD 0.06
Wavelength Change   246 nm   248 nm  
Sr No Conc. µg/ml Area Sr No Conc. µg/ml Area
1 50 3568.71 1 50 3530.68
2 50 3569.6 2 50 3531.29
  Mean 3569.2   Mean 3531.0
  SD 0.63   SD 0.43
  %RSD 0.02   %RSD 0.01