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Table 2 Screening variables and their levels (in coded and actual) used for 32 factorial design

From: Experimental design approach, screening and optimization of system variables, analytical method development of flurbiprofen in nanoparticles and stability-indicating methods for high-pressure liquid chromatography

Independent variables Level used, actual (coded)  
  (− 1) (0) (+ 1)
X1 = Flow rate (ml/min) 1 1.1 1.2
X2 = Temperature (°C) 20 22.5 25
X3 = Methanol (%) 80 82.5 85