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Table 2 Screening variables and their levels (in coded and actual) used for 32 factorial design

From: Experimental design approach, screening and optimization of system variables, analytical method development of flurbiprofen in nanoparticles and stability-indicating methods for high-pressure liquid chromatography

Independent variables

Level used,

actual (coded)

 
 

(− 1)

(0)

(+ 1)

X1 = Flow rate (ml/min)

1

1.1

1.2

X2 = Temperature (°C)

20

22.5

25

X3 = Methanol (%)

80

82.5

85