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Table 3 Full factorial design matrix (in coded level) along with optimized formulation and experimental data

From: Experimental design approach, screening and optimization of system variables, analytical method development of flurbiprofen in nanoparticles and stability-indicating methods for high-pressure liquid chromatography

   Factor 1 Factor 2 Factor 3 Response 1 Response 2 Response 3 Response 4
Std Run A:Flow Rate B:Temp C:Methanol RT PA TF TP
   ml/min Celcius % Min AUC   
17 1 1.1 25 82.5 4.4 3925.52 0.72 9703
12 2 1.2 20 82.5 4 3604.91 0.75 8948
4 3 1 22.5 80 5.51 4321.57 0.72 10,240
18 4 1.2 25 82.5 4.04 3596.22 0.74 9050
14 5 1.1 22.5 82.5 4.49 3931.8 0.73 9576
2 6 1.1 20 80 5.02 3935.56 0.73 9202
10 7 1 20 82.5 4.95 4309.67 0.72 9981
27 8 1.2 25 85 3.69 3596.32 0.74 8684
16 9 1 25 82.5 4.85 4322.46 0.72 10,175
25 10 1 25 85 4.39 4328.81 0.72 10,165
7 11 1 25 80 5.61 4315.05 0.74 10,901
15 12 1.2 22.5 82.5 4.06 3592.36 0.74 8926
1 13 1 20 80 5.88 4319.99 0.73 9774
26 14 1.1 25 85 3.84 3922.21 0.73 9378
24 15 1.2 22.5 85 3.54 3599.88 0.74 8819
13 16 1 22.5 82.5 4.91 4319.04 0.72 10,110
20 17 1.1 20 85 3.9 3916.94 0.73 9409
22 18 1 22.5 85 4.25 4311.75 0.71 10,007
6 19 1.2 22.5 80 4.58 3596.63 0.74 9054
8 20 1.1 25 80 4.91 3937.21 0.73 9557
3 21 1.2 20 80 4.68 3596.83 0.75 9687
11 22 1.1 20 82.5 4.5 3933.82 0.73 9407
5 23 1.1 22.5 80 4.98 3953.49 0.73 9556
23 24 1.1 22.5 85 3.88 3919.34 0.73 9319
21 25 1.2 20 85 3.75 3603.87 0.74 8730
19 26 1 20 85 4.22 4323.15 0.72 9713
9 27 1.2 25 80 4.68 3596.83 0.75 9687