Experimental design approach, screening and optimization of system variables, analytical method development of flurbiprofen in nanoparticles and stability-indicating methods for high-pressure liquid chromatography

Future Journal of Pharmaceutical Sciences

Table 4 Statistics for the model of response

Responses	Source	Std. Dev	R²	Adjusted R²	Predicted R²	Press
Retention time	Linear	0.1235	0.9632	0.9584	0.9439	0.5342	–
	2FI	0.1041	0.9773	0.9704	0.9376	0.5943	–
	Quadratic	0.0872	0.9864	0.9792	0.9583	0.3972	Suggested
	Cubic	0.0918	0.9912	0.9770	0.9042	0.9133	–
Peak area	Linear	16.13	0.9974	0.9971	0.9965	8136.06	–
	2FI	17.18	0.9975	0.9967	0.9952	11,159.82	–
	Quadratic	8.39	0.9995	0.9992	0.9986	3186.86	Suggested
	Cubic	6.00	0.9998	0.9996	0.9986	3198.84	–
Tailing factor	Linear	0.0056	0.7519	0.7195	0.6431	0.0010	Suggested
	2FI	0.0057	0.7774	0.7106	0.4691	0.0016	–
	Quadratic	0.0051	0.8492	0.7693	0.5781	0.0012	–
	Cubic	0.0045	0.9309	0.8203	0.4818	0.0015	–
Theoretical plate	Linear	245.23	0.8122	0.7877	0.7160	2.092E + 06	Suggested
	2FI	214.75	0.8748	0.8372	0.6889	2.291E + 06	Suggested
	Quadratic	216.35	0.8920	0.8348	0.6639	2.475E + 06	–
	Cubic	202.26	0.9445	0.8556	0.4473	4.071E + 06	–