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Table 1 The experimental composition and results of simplex-lattice design

From: Formulation development, optimization and characterization of Pemigatinib-loaded supersaturable self-nanoemulsifying drug delivery systems

Expt

Amount of oil

Amount of surfactant

Amount of co-surfactant

Droplet size (nm)

Polydispersity index

Drug release at 15 min (%)

1

0.5

0

0.5

298.73

0.383

23.38

2

0.5

0.5

0

321.45

0.408

17.12

3

0.66666

0.166667

0.166667

355.34

0.406

19.43

4

0

0.5

0.5

179.92

0.288

19.32

5

0

0

1

165.56

0.242

20.88

6

0.5

0.5

0

314.43

0.414

17.74

7

0.16666

0.666667

0.166667

233.12

0.312

19.12

8

0

0

1

172.66

0.27

20.62

9

0

1

0

201.64

0.329

18.88

10

1

0

0

438.46

0.514

15.86

11

0.16666

0.166667

0.666667

222.12

0.296

21.26

12

1

0

0

438.34

0.512

16.46

13

0

1

0

192.48

0.292

19.12

14

0.33333

0.333333

0.333333

265.22

0.368

21.22