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Future Journal of Pharmaceutical Sciences

Table 3 ANOVA table of all the three polynomial models

From: Formulation development, optimization and characterization of Pemigatinib-loaded supersaturable self-nanoemulsifying drug delivery systems

Source of variations

Sum of squares

Degrees of freedom

Mean square values

F-value

P-value

Prob > F

 

Y1—Droplet size

Model

112,124.2

2

56,062.11

4100.14

 < 0.0001

Significant

Linear Mixture

112,124.2

2

56,062.11

4100.14

 < 0.0001

 

Residual

150.4054

11

13.67322

   

Lack of Fit

58.60021

7

8.371458

0.364749

0.8842

Not significant

Pure Error

91.8052

4

22.9513

   

Cot Total

112,274.6

13

    

Y2—Polydispersity index

Model

0.091389

2

0.045694

197.0463

 < 0.0001

Significant

Linear Mixture

0.091389

2

0.045694

197.0463

 < 0.0001

 

Residual

0.002551

11

0.000232

   

Lack of Fit

0.001454

7

0.000208

0.757922

0.6495

Not significant

Pure Error

0.001097

4

0.000274

   

Cot Total

0.093939

13

    

Y3—Drug release at 15 min

Model

54.53438

3

18.17813

149.0781

 < 0.0001

Significant

Linear Mixture

28.74925

2

14.37462

117.8857

 < 0.0001

 

AC

25.78513

1

25.78513

211.4629

 < 0.0001

 

Residual

1.219369

10

0.121937

   

Lack of Fit

0.784569

6

0.130762

1.202958

0.4487

Not significant

Pure Error

0.4348

4

0.1087

   

Cot Total

55.75375

13

    
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