From: Artemisia vulgaris Linn: an updated review on its multiple biological activities
Pharmacological action | Evidence | Responsible compounds | References |
---|---|---|---|
Analgesic | Slightly marginal anti-nociceptive effect | Maybe due to hydroxybenzoic acid derivatives, rutoside and caffeic acid its derivatives | [49] |
Anthelmintic | Action in contradiction of Trichinella spiralis | NA | [50] |
Antimalarial | Action in contradiction Plasmodiumyoelii and P. berghei | NA | [57] |
Antiallergenic | Diminution in eye and skin sensitivity | NA | [58] |
Antifungal and antibacterial | Oil fraction showed inhibitory action on the expansion of Aspergillus niger, Escherichia coli, Candida albicans, Salmonella enteritidis, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Streptococcus mutans | Maybe due to the presence of essential oils, camphen, 1,8-cineole and α-thujone | |
Antihypertensive | Decrease the hypertensive action of noradrenaline. Moxibustion, when contrasted to antihypertensive medications, reduced blood pressure by activating acupoint KI 1 | NA** Moxibustion is a traditional Chinese practice of stimulating acupuncture sites by using the warmth created by scorching herbal provisions using A. vulgaris | |
Antispasmolytic | H1 histamine receptor antagonism | NA | |
Anti-inflammatory | Quantization of blood fat profile, elevation of paraoxonase-1 actions, and reduction of serum malondialdehyde, nitric oxide and tumor necrosis factor-α level. The “Cotton Pellet Granuloma Method” and a lipoxygenase (LOX) inhibitory activity experiment were used to confirm it | NA | |
Hypolipemic | Standardized serum lipid spectrum, elevated paraoxonase-1 function, lowered serum malondialdehyde, nitric oxide, tumor necrosis factor and hydroxymethylglutaryl-CoA reductase action. Increasing HDL and decreasing total cholesterol, triglycerides, LDL, and VLDL while diminishing atherogenicity (aqueous extract of A. vulgaris roots) | NA | |
Hepatoprotective | Prophylactic therapeutic potential in the liver parenchyma, decreasing inflammation, cellular edema, apoptotic cell count and hyperemia | [28] | |
MAO inhibition | Mouse brain monoamine oxidase (MAO) enzyme restriction | Coumarins: scopoletin, esculetin, esculetin-6-methylether, flavonoids: apigenin, quercetin, luteolin, jaceosidin, eupafolin | [53] |
Estrogenic | The estrogen receptor is antagonistic, and gene transcription is activated. Eriodictyol and apigenin promote gene transcription. Female Wistar rats with anti-implantation and estrogenic activities | Flavonoids | |
Cytotoxic | Suppression of tumor cell proliferation in HeLa, A7R5, MCF7, 293 T, HL-60 and SW-480 cancer cell lines | Essential oil, flavonoids, phenolic compounds |