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Table 6 Reported pharmacological activities of Artemisia vulgaris

From: Artemisia vulgaris Linn: an updated review on its multiple biological activities

Pharmacological action

Evidence

Responsible compounds

References

Analgesic

Slightly marginal anti-nociceptive effect

Maybe due to hydroxybenzoic acid derivatives, rutoside and caffeic acid its derivatives

[49]

Anthelmintic

Action in contradiction of Trichinella spiralis

NA

[50]

Antimalarial

Action in contradiction Plasmodiumyoelii and P. berghei

NA

[57]

Antiallergenic

Diminution in eye and skin sensitivity

NA

[58]

Antifungal and antibacterial

Oil fraction showed inhibitory action on the expansion of Aspergillus niger, Escherichia coli, Candida albicans, Salmonella enteritidis, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Streptococcus mutans

Maybe due to the presence of essential oils, camphen, 1,8-cineole and α-thujone

[8, 35, 45, 46]

Antihypertensive

Decrease the hypertensive action of noradrenaline. Moxibustion, when contrasted to antihypertensive medications, reduced blood pressure by activating acupoint KI 1

NA** Moxibustion is a traditional Chinese practice of stimulating acupuncture sites by using the warmth created by scorching herbal provisions using A. vulgaris

[4, 7, 10, 59]

Antispasmolytic

H1 histamine receptor antagonism

NA

[10, 11]

Anti-inflammatory

Quantization of blood fat profile, elevation of paraoxonase-1 actions, and reduction of serum malondialdehyde, nitric oxide and tumor necrosis factor-α level. The “Cotton Pellet Granuloma Method” and a lipoxygenase (LOX) inhibitory activity experiment were used to confirm it

NA

[60, 40, 61]

Hypolipemic

Standardized serum lipid spectrum, elevated paraoxonase-1 function, lowered serum malondialdehyde, nitric oxide, tumor necrosis factor and hydroxymethylglutaryl-CoA reductase action. Increasing HDL and decreasing total cholesterol, triglycerides, LDL, and VLDL while diminishing atherogenicity (aqueous extract of A. vulgaris roots)

NA

[54, 56]

Hepatoprotective

Prophylactic therapeutic potential in the liver parenchyma, decreasing inflammation, cellular edema, apoptotic cell count and hyperemia

 

[28]

MAO inhibition

Mouse brain monoamine oxidase (MAO) enzyme restriction

Coumarins: scopoletin, esculetin, esculetin-6-methylether, flavonoids: apigenin, quercetin, luteolin, jaceosidin, eupafolin

[53]

Estrogenic

The estrogen receptor is antagonistic, and gene transcription is activated. Eriodictyol and apigenin promote gene transcription. Female Wistar rats with anti-implantation and estrogenic activities

Flavonoids

[3, 62, 52]

Cytotoxic

Suppression of tumor cell proliferation in HeLa, A7R5, MCF7, 293 T, HL-60 and SW-480 cancer cell lines

Essential oil, flavonoids, phenolic compounds

[60, 63,64,65]

  1. **NA stands for no data