From: 3D printing of pharmaceuticals: approach from bench scale to commercial development
Sr. No | Active pharmaceutical ingredient | Polymer | Novelty in formulation | References |
---|---|---|---|---|
1 | Fluorescein | PVA | The drug load is 0.29% with strong appearance of tablet. No drug degradation with modified release profile | [30] |
2 | Pramipexole | Eudragit EPO PEO | Drug release occurred within 5Â min. No use of any disintegrating/filling agents | [60] |
3 | Theophylline | PVP | Reduce temperature and prepared IR tablet with talc | [61] |
4 | Pantoprazole sodium | PEG 6000 PVP K 12 | Thermo-sensitive drug processed below 1000 C. Infill % lowers down to 50% help to reduce drug release up to 3Â min | [62] |
5 | Paracetamol | PVP K12 and CCS | Oral-shaped tablet, Considering high dose prepared specially for drug release more than 90% within first 10Â min | [63] |
6 | Paracetamol | PVA | 4% drug load, different geometrical shapes are used such as pyramid, torus, cube, sphere, cylinder by keeping surface area constant | [32] |
7 | Hydrochlorothiazide | Eudragit E | Channeled tablet design. Increase surface area of tablet with media perforation through its structure. The shorter channels give more efficient drug release than the longer channels | [65] |
8 | Prednisolone | PVA | High thermal stability and neutral nature. Flexible dose ellipse-shaped tablets for drug release over the 24Â h | [43] |
9 | Metformin | PVA | Egg-shaped tablet giving immediate drug release. Prepared as model drug for abuse deterrent formulation. It is well proven that it cannot break easily | [66] |
10 | Isoniazid Rifampicin | PEO | Different compartments are made so as to release drug as per its requirement. Anti-tuberculosis drug used can slower release and absorption of drug | [68] |
11 | Theophylline | Eudragit RL, Eudragit RS | Thermostable drug. With polymer Eudragit RL gives immediate and Eudragit RS gives extended drug release. The caplet form gives ease in the swallowing | [40] |
12 | Ramipril | Kollidon VA 64 Kollidon 12 PF | Drug melting point is 1090C. No degradation observed due to use of proper combination. Choice of combination becomes important so as to overcome degradation problem due to thermal heating process | [70] |