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Table 2 Plasma pharmacokinetics study of Cur-ME and Cur-Sol in rats (n = 8)

From: Exploring the protective effect exhibited by curcumin-loaded coconut oil microemulsion in the experimental models of neurodegeneration: an insight of formulation development, in vitro and in vivo study

Parameter

Unit

Value

Cur-Sol

Cur-ME

t1/2

h

0.767 ± 0.450

0.636 ± 0.056

Tmax

h

1.000

1.000

Cmax

μg/ml

0.085 ± 0.018

0.210 ± 0.014

AUC 0-t

μg/ml*h

0.148 ± 0.009

0.296 ± 0.013

AUC 0-inf_obs

μg/ml*h

0.166 ± 0.023

0.318 ± 0.014

AUMC 0-inf_obs

μg/ml*h^2

0.265 ± 0.133

0.402 ± 0.032

MRT 0-inf_obs

h

1.548 ± 0.554

1.263 ± 0.064