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Future Journal of Pharmaceutical Sciences
Fig. 1 | Future Journal of Pharmaceutical Sciences

Fig. 1

From: In-silico and in-vitro analysis of novel substituted benzimidazolyl derivatives for antimycobacterial potentials targeting enoyl acyl carrier protein reductase (InhA)

Fig. 1

Steps involved in the scheme preparation and the structure of parent molecules where the substitution was made. AR = (4-chlorophenyl, 4-flurophenyl, 4-tolyl); AR’ = (4-carboxyphenyl, 2-hydroxy, 4-carboxy phenyl), AR’’ = (Nicotinoyl, phenyl, benzoyl). (i) Conc. Hcl at 100 ℃ for 30 min, (ii) 90% acetic acid at 75 ℃ for 45 min, (iii) C2H5OH for 3 h / add Conc. NH3 till product precipitation, (iv) C2H5OH / NaOH; stirred for 4 h; left overnight, (v) Glacial CH3COOH/H2O2; 3 h; kept overnight

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