Future Journal of Pharmaceutical Sciences

Table 3 Docking interactions of selected lead compounds

From: In-silico and in-vitro analysis of novel substituted benzimidazolyl derivatives for antimycobacterial potentials targeting enoyl acyl carrier protein reductase (InhA)

Compound	H-Bond	Pi-Pi stacking
4	ILE 194, LYS 165	PHE 149
5a	ILE 194	NIL
5b	ILE 194, TYR 158	NIL
5c	ILE 194, TYR 158	NIL
5d	LYS 165	NIL
5e	TYR 158	NIL
5f	ILE 194, TYR 158	NIL
INH	TYR 158	NIL

According to previous literature four amino acid interactions namely TYR 158, ILE 194, PHE 149 and LYS 165 are crucial for InhA inhibitory activity [29,30,31]

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