Future Journal of Pharmaceutical Sciences

Table 4 Preliminary QikProp ADME predicted data for the seven best lead molecules

From: In-silico and in-vitro analysis of novel substituted benzimidazolyl derivatives for antimycobacterial potentials targeting enoyl acyl carrier protein reductase (InhA)

Compound	CNS	log HERG	Pcaco (nm/s)	logBB	PMDCK (nm/s)	% HOA	Ro5	Ro3
4	0	− 5.619	1357.62	− 0.46	1696.26	100	0	0
5a	1	− 8.035	503.807	− 0.06	542.518	100	0	0
5b	− 1	− 6.746	682.273	− 0.92	806.375	100	0	0
5c	− 2	− 5.28	508.94	− 1.04	326.529	87.52	0	0
5d	− 1	− 6.768	679.022	− 0.98	587.325	100	0	0
5e	1	− 8.02	504.055	− 0.24	261.002	100	0	0
5f	− 2	− 6.863	580.952	− 1.19	275.051	100	0	0

*HOA (Human oral absorption), Ro5 (Rule of five), Ro3 (Rule of three)

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