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Future Journal of Pharmaceutical Sciences

Table 5 Summary of pharmacokinetic data of CXB and ACF in all three groups

From: Effect of Andrographis paniculata extract and Andrographolide on the pharmacokinetics of Aceclofenac and Celecoxib in rats

Parameters

CXB

ACF

Group A (CXB)

Group B (CXB + AND)

Group C (CXB + APE)

Group A (ACF)

Group B (ACF + AND)

Group C (ACF + APE)

Cmax (μg mL−1)

2.97 ± 0.02

2.79 ± 0 .12#

3.40 ± 0.3**

3.86 ± 0.35

5.91 ± 0.98***

6.79 ± 0.41***

Tmax (h)

1.5

4**

6**

0.33 ± 0.00

0.08 ± 0.00

0.17 ± 0.00

AUC 0 to t (μg h mL−1)

30.79 ± 1.66

29.47 ± 0.95

31.88 ± 0.9

4.00 ± 0.44

1.75 ± 0.08***

2.49 ± 0.13***###

AUC0-∞ (μg h mL−1)

145.48 ± 15.42

146.93 ± 9.84

139.33 ± 11.1

6.17 ± 0.94

2.14 ± 0.17***

2.58 ± 0.13***

AUMC 0 to t (μg h2 mL−1)

190.71 ± 9.51

175.94 ± 5.15

195.83 ± 4.7

11.14 ± 1.67

0.85 ± 0.03***

1.03 ± 0.05***

AUMC0-∞ (μg h2 mL−1)

7684.17 ± 1301.88

7173.47 ± 850.81

23,822.06 ± 785.3

71.64 ± 20.77

5.88 ± 4.02***

1.68 ± 0.04***

Vd (mL)

195.81 ± 16.95

182.52 ± 27.61

177.45 ± 28.9

832.33 ± 87.36

348.54 ± 65.62***

218.63 ± 24.01***#

CL (mL h−1)

31.60 ± 2.49

30.57 ± 4.59#

28.89 ± 3.1**

300.96 ± 35.53

711.79 ± 80.56***

525.85 ± 48.89***###

t1/2 (h)

31.09 ± 2.17

31.08 ± 2.67

30.49 ± 1.86

4.52 ± 0.43

1.09 ± 0.40***

0.43 ± 0.01***##

MRTa0 to t (h)

6.19 ± 0.11

5.97 ± 0.03***

6.14 ± 0.04#

2.77 ± 0.17

0.48 ± 0.04***

0.41 ± 0.01***

MRT0-∞ (h)

53.02 ± 8.81

48.80 ± 4.64

56.88 ± 5.54

11.46 ± 1.73

2.66 ± 1.65***

0.65 ± 0.02***

  1. Values are expressed as one-way ANOVA followed by Bonferronis multi comparison test n = 6, mean ± SD ***P < 0.0001 versus Group A, **P < 0.001, *P < 0.01, #P > 0.05
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