Compounds | 13 | 31 | 33 | Reference |
---|---|---|---|---|
GIA (% Absorbed) | 97.47 | 97.50 | 100 | 81.51 |
LogKP (skin permeation) | − 5.24 | − 5.43 | − 5.64 | − 2.5 |
P-gp S | Yes | Yes | Yes | No |
CaCo2 (log Papp in 10–6 cm/s) | 1.16 | 1.11 | 1.16 | 0.11 |
CYP 3A4 | No | Yes | Yes | No |
CYP 2D6 | No | No | No | Yes |
Hepatotoxicity | No | No | No | No |