Table 1 Pharmacokinetic parameters of metoprolol succinate in the presence or absence of hesperetin (25, 50, and 100 mg/kg) on the 1st day (n = 6)
From: Effect of hesperetin on the pharmacokinetics of metoprolol succinate in rats
PK Parameter | MTL 30 mg/kg | MTL + HSP 25 mg/kg | MTL + HSP 50 mg/kg | MTL + HSP 100 mg/kg |
|---|---|---|---|---|
Cmax (µg/mL) | 3.871 ± 0.856 | 6.696 ± 2.544*** | 14.086 ± 4.362*** | 18.962 ± 4.115*** |
AUC0–24 (µg/mL/h) | 27.876 ± 3.685 | 70.797 ± 6.955*** | 114.615 ± 9.690*** | 138.743 ± 10.152*** |
AUC0–∞ (µg/mL/h) | 35.526 ± 4.647 | 116.648 ± 9.599*** | 177.606 ± 12.354*** | 207.415 ± 16.955*** |
t1/2 (h) | 12.128 ± 3.477 | 19.261 ± 4.120** | 15.811 ± 3.266* | 16.495 ± 2.547** |
Tmax (h) | 0.5 ± 0.1 | 0.5 ± 0.15 | 1.0 ± 0.2* | 0.5 ± 0.15 |
MRT (h) | 15.126 ± 3.771 | 26.104 ± 3.545** | 22.545 ± 3.251* | 20.377 ± 3.488* |
CL/F (mL/h/Kg) | 0.059 ± 0.005 | 0.030 ± 0.006** | 0.039 ± 0.007** | 0.027 ± 0.007** |
Vz/F (mL/Kg) | 1.600 ± 0.071 | 0.783 ± 0.068** | 0.888 ± 0.075* | 1.175 ± 0.358* |