Table 2 Pharmacokinetic parameters of metoprolol succinate in the presence or absence of hesperetin (25, 50, and 100 mg/kg) on the 15th day (n = 6)
From: Effect of hesperetin on the pharmacokinetics of metoprolol succinate in rats
PK Parameter | MTL 30 mg/kg | MTL + HSP 25 mg/kg | MTL + HSP 50 mg/kg | MTL + HSP 100 mg/kg |
|---|---|---|---|---|
Cmax (µg/mL) | 4.783 ± 1.585 | 8.569 ± 2.441** | 17.863 ± 3.874*** | 21.664 ± 5.695*** |
AUC0–24 (µg/mL/h) | 44.947 ± 6.112 | 71.013 ± 6.254** | 103.087 ± 7.265*** | 210.293 ± 15.141*** |
AUC0–∞ (µg/mL/h) | 67.739 ± 5.455 | 93.318 ± 7.635* | 309.381 ± 15.622*** | 298.582 ± 21.845*** |
t1/2 (h) | 14.637 ± 3.444 | 17.704 ± 2.845* | 18.192 ± 4.787* | 20.243 ± 2.480** |
Tmax | 0.5 ± 0.12 | 0.5 ± 0.12 | 1.0 ± 0.25 | 0.5 ± 0.15 |
MRT (h) | 22.193 ± 3.890 | 26.817 ± 3.877 | 38.678 ± 3.515** | 28.331 ± 2.588* |
CL/F (L/h/Kg) | 10.333 ± 2.515 | 3.750 ± 0.858** | 2.262 ± 0.577*** | 4.688 ± 1.220** |
Vz/F (mL/Kg) | 1.248 ± 0.355 | 0.630 ± 0.245** | 0.875 ± 0.362* | 0.859 ± 0.284* |