Application of Box–Behnken design and desirability function in the development and optimization of self-nanoemulsifying drug delivery system for enhanced dissolution of ezetimibe

Future Journal of Pharmaceutical Sciences

Table 3 Observed responses from randomized runs in the Box–Behnken design

Run	Formula-tion code	Globule size (nm) (Y₁)	PDI	Zeta potential (mV)	Transmittance (%) (Y₂)	Self-emulsification time (sec) (Y₃)	% drug release after 5 min (Y₄)	% drug release after 40 min (Y₅)
1	F1	55.3 ± 3.08	0.275	− 25.5 ± 6.46	100.1 ± 3.46	90 ± 1.33	38.17 ± 2.64	70.54 ± 3.54
2	F2	45.7 ± 2.89	0.287	− 23.9 ± 5.81	100.8 ± 2.94	82 ± 2.54	40.27 ± 2.98	75.62 ± 3.02
3	F3	102.1 ± 8.88	0.444	− 17 ± 4.73	93.8 ± 5.61	182 ± 4.67	32.22 ± 2.11	58.21 ± 2.14
4	F4	76.8 ± 3.65	0.298	− 22.9 ± 4.81	97.2 ± 4.32	145 ± 5.12	36.19 ± 2.14	66.72 ± 2.11
5	F5	55.8 ± 2.14	0.299	− 26.2 ± 3.35	100.3 ± 2.54	94 ± 3.31	39.85 ± 2.13	71.29 ± 2.56
6	F6	89.9 ± 3.57	0.302	− 18.3 ± 3.37	98.2 ± 2.15	170 ± 4.98	33.29 ± 1.97	60.16 ± 2.81
7	F7	81.83 ± 2.68	0.271	− 23.9 ± 6.38	98.5 ± 3.68	125 ± 4.41	34.09 ± 2.56	63.45 ± 2.49
8	F8	24.4 ± 2.07	0.247	− 26.4 ± 6.52	101.2 ± 1.97	55 ± 3.54	49.21 ± 2.99	95.27 ± 2.38
9	F9	76.2 ± 3.02	0.315	− 24 ± 5.15	97.4 ± 2.41	118 ± 2.63	34.62 ± 3.03	65.81 ± 2.62
10	F10	31.8 ± 2.15	0.276	− 26.3 ± 2.48	99.3 ± 3.15	67 ± 1.14	43.18 ± 2.91	84.21 ± 2.51
11	F11	56 ± 3.27	0.322	− 26.1 ± 3.64	100.2 ± 4.81	97 ± 1.89	39.13 ± 2.10	70.85 ± 1.45
12	F12	32.2 ± 2.08	0.259	− 16.6 ± 3.52	98.1 ± 3.12	68 ± 2.14	45.69 ± 2.13	91.23 ± 3.05
13	F13	38.8 ± 2.45	0.268	− 27.1 ± 5.88	97.9 ± 3.65	85 ± 3.05	41.56 ± 1.95	78.26 ± 2.33
14	F14	63.91 ± 3.91	0.308	− 11.2 ± 3.52	97.6 ± 2.88	105 ± 2.54	37.02 ± 3.13	68.61 ± 2.84
15	F15	38.4 ± 2.31	0.302	− 21.7 ± 5.08	98.7 ± 2.69	70 ± 2.96	42.17 ± 2.52	82.24 ± 2.08