Articles

A pharmacognostic approach for mitigating pancreatic cancer: emphasis on herbal extracts and phytoconstituents

Pancreatic cancer is studied as one of the most lethal cancers with currently no control of its lethality, mainly due to its late diagnosis and lack of foolproof treatment processes. Despite continuous efforts...

Authors: Shruti Gupta, Atul Kumar and Kiran Kumar Tejavath

Development and validation of stability-indicating UPLC method for the determination of gliclazide and its impurities in pharmaceutical dosage forms

For the determination of gliclazide and its three potential impurities quantitatively, the development of a stability-indicating, accurate, simple, and fast, Ultra-Performance Liquid Chromatography (UPLC) meth...

Authors: Kunal Bhattacharya and Jane Mathew

Concurrent estimation of lamivudine, tenofovir disoproxil fumarate, and efavirenz in blended mixture and triple combination tablet formulation by a new stability indicating RP-HPLC method

An easy, defined, rapid, and accurate reverse phase high-performance liquid chromatography method was developed and subsequently validated for the concurrent estimation of lamivudine, efavirenz, and tenofovir ...

Authors: Ramreddy Godela, Vijayalaxmi Kammari, Sowjanya Gummadi and Durgaprasad Beda

Simple and efficient method for the quantification of antiepileptic drugs in human plasma by using magnetic graphene oxide-β-cyclodextrin composite as a sorbent

In recent days, solid-phase extraction methods are widely utilized for the extraction of drug molecules from plasma samples due to their easy operating procedures and low matrix effect. The trace-level solid-p...

Authors: Babji Palakeeti, K. Vijendar Reddy, K. Vengatajalabathy Gobi, Pothuraju Nageswara Rao and Jugun Prakash Chinta

Design and optimization of nano invasomal gel of Glibenclamide and Atenolol combination: in vitro and in vivo evaluation

There are many circumstances where chronic disease is associated with other disorders, especially in diseases such as diabetes with noncommunicable disease risk factors, such as hypertension. The current thera...

Authors: P. Anitha and S. V. Satyanarayana

Strobilanthes heyneanus root extract as a potential source for antioxidant and antimicrobial activity

Strobilanthes heyneanus (Nilgirianthus heyneanus) belongs to the family Acanthaceae that contains many species with potential for diverse medicinal uses. It is also called ‘Karun kurinji’ and is commonly found in...

Authors: Vijayakumar Sundaram, Selvaraju Sadhasivam, Sivaraj Chandrasekaran, Raaman Nanjian and Arjun Pandian

Reverse phase-liquid chromatography assisted protocol for simultaneous determination of lamivudine and tenofovir disoproxil fumarate in combined medication used to control HIV infection: an investigative approach

Human immunodeficiency virus (HIV) causes severe life-threatening condition, i.e., AIDS. HIV destabilises an individual’s ability to prevent infection. Therefore, the combine medication lamivudine (LVD) and te...

Authors: Vaibhav S. Adhao, Suraj R. Chaudhari, Jaya P. Ambhore, Sunil Sangolkar, Raju R. Thenge, Rameshwar S. Cheke and Amod S. Patil

Pharmacological comparison of four biopolymeric natural gums as hemostatic agents for management of bleeding wounds: preliminary in vitro and in vivo results

Uncontrolled bleeding is one of the primary reasons for preventable death in both civilian trauma and military battle field. This study evaluates in vitro and in vivo hemostatic potential of four biopolymeric nat...

Authors: Himanshu Kushwah, Nidhi Sandal, Meenakshi Chauhan and Gaurav Mittal

Evaluation of physicochemical stability and degradation kinetics of bedaquiline in hydrolytic solutions of different pH

Tuberculosis is an infection that has high mortality rate in human as well as in animals if it remains unattained for long time. Scientists are always desirous to discover new molecules against Mycobacterium tube...

Authors: S. J. Rajput and P. J. Vanavi

Development and validation of stability-indicating RP-HPLC method for estimation of dalfampridine in bulk drug and tablet dosage form

In the current study, a simple, improved, precise, rapid, and accurate reverse phase liquid chromatographic method was produced for the estimation of dalfampridine in bulk and tablet dosage form which is a pot...

Authors: Dipali Bagal, Akhil Nagar, Aditya Joshi, Aishwarya Chachare, Atul Shirkhedkar and Saurabh Khadse

Novel stability-indicating RP-UPLC method for simultaneous estimation of sitagliptin and ertugliflozin in bulk and pharmaceutical formulations

The present investigation was proposed to develop a simple, sensitive, rapid, accurate, precise stability-indicating RP-UPLC method for simultaneous estimation of sitagliptin and ertugliflozin. Chromatographic...

Authors: Ramya kuber B and Swetha Addanki

Multivariate optimization of liquid chromatographic conditions for determination of dapagliflozin and saxagliptin, application to an in vitro dissolution and stability studies

Analytical quality by design driven HPLC method has been optimized for simultaneous estimation of dapagliflozin and saxagliptin in pharmaceutical dosage form. Response surface methodology was employed for opti...

Authors: Sunitha Gurrala, Shiva Raj, C. V. S. Subrahmanyam and Panikumar D. Anumolu

Present and future treatment strategies for coronavirus disease 2019

The recent pandemic of coronavirus disease 2019 (COVID-19) has resulted in many challenges to the healthcare organizations around the world. Unfortunately, until now, there are no proven effective therapeutic ...

Authors: Engy Elekhnawy, Amal Abo Kamar and Fatma Sonbol

Stability indicating thin-layer chromatographic method for estimation of antidiabetic drug Remogliflozin etabonate

A sensitive, precise, and stability-indicating high-performance thin-layer chromatographic (HPTLC) method has been developed for the analysis of Remogliflozin etabonate in tablet formulation. HPTLC plates prec...

Authors: Dimal A. Shah, Ishita I. Gondalia, Vandana B. Patel, Ashok Mahajan, Usmangani Chhalotiya and Dhruti C. Nagda

Ameliorative effect of Allium atroviolaceum on sperm quality in cyclophosphamide-treated mice

Cyclophosphamide (CP) is an anti-neoplastic alkylating agent that is extensively used in different chemotherapy regimens. Adverse effects on the reproductive system, especially spermatogenesis, are one of the ...

Authors: Alireza Hosseini, Mehrdad Shahrani, Shirin Asgharian, Maryam Anjomshoa, Ayoob Rostamzadeh, Zahra Lorigooini, Najmeh Asgharzadeh and Abbas Azari

Cystitis treatment with phytotherapy within the Rif, Northern Morocco

Cystitis is often caused by a bacterial infection, which is the most widespread type among other urinary infections. This investigation was aimed to document detailed ethnobotanical information of medicinal pl...

Authors: Noureddine Chaachouay, Hicham Orch and Lahcen Zidane

In vivo bioactivity-guided isolation of antifertility fraction of Waltheria indica Linn. root in male Wistar rats

Waltheria indica is a multipurpose medicinal plant with abundance of phytochemical compounds. Antifertility effect of Waltheria indica Linn. root and leaves have been reported. However, the fraction responsible f...

Authors: Basiru Afisu, Aremu Abdulfatah, Azeez Oyebisi Mistura, Soetan Kehinde Olugboyega and Olayemi Funsho Olakitike

Antilithiatic effect of C. dactylon, E. officinalis, K. pinnata, and B. nutans ethyl acetate fraction on glyoxylate-induced nephrolithiasis

The plants Cynodon dactylon (C. dactylon), Emblica officinalis (E. officinalis), Kalanchoe pinnata (K. pinnata), and Bambusa nutans (B. nutans) have been reported to possess diuretic and antiurolithiatic potentia...

Authors: Papiya Bigoniya, Atul Kumar Sohgaura and Birendra Shrivastava

In vitro antibacterial and in silico docking studies of two Schiff bases on Staphylococcus aureus and its target proteins

Schiff base compounds have extensive applications in various fields such as analytical, inorganic, organic, and biological fields. They have excellent pharmacology application prospects in the modern era and a...

Authors: Ragi K, Joby Thomas Kakkassery, Vinod P. Raphael, Reeja Johnson and Vidhya Thomas K

Development of new stability indicating UPLC-UV method for the extraction and quantification of perindopril and indapamide from human plasma

The hypertension and cardiovascular ailments are the leading cause of deaths worldwide. The combination therapy was found to be effective on the cardiovascular illness by reducing the blood pressure. The indap...

Authors: Babji Palakeeti, Pothuraju Nageswara Rao and Jugun Prakash Chinta

Evaluation of in vitro antioxidant, anticancer activities and molecular docking studies of Capparis zeylanica Linn. leaves

Capparis zeylanica Linn. leaf extract was subjected to phytochemical screening for the determination of antioxidant and anticancer activity on (MCF-7) human breast cancer cells. The phytoconstituents previously d...

Authors: Ruturaj A. Warake, Ravindra J. Jarag, Rakesh P. Dhavale, Rekha R. Jarag and Nikhil S. Lohar

Green chemistry approach: method development and validation for identification and quantification of entecavir using FT-IR in bulk and pharmaceutical dosage form

Chemical hazard is one of the most prominent side effects that come out along with the benefits of pharmaceutical production. Chemicals usage and waste production are involved in each step of production and ar...

Authors: Asia Naz, Itrat Tabish, Ayesha Naseer, Ahsan Zamir Siddiqi, Farhan Ahmed Siddiqui and Agha Zeeshan Mirza

Biological activities of limonoids in the Genus Khaya (Meliaceae): a review

Limonoids are a class of highly oxygenated modified triterpenoids with a diverse range of biological activities. Although with restricted occurrence in the plant kingdom, these compounds are found extensively ...

Authors: Tomi Lois Olatunji, Christiana Adeyinka Odebunmi and Ademola Emmanuel Adetunji

Risk of SARS-CoV-2 infection and COVID-19 prognosis with the use of renin–angiotensin–aldosterone system (RAAS) inhibitors: a systematic review

Angiotensin-converting-enzyme-2, being the receptor for SARS-CoV-2, is increased in the use of RAAS inhibitors. Therefore, concerns have been raised over risks of SARS-CoV-2 infection and poor prognosis of COV...

Authors: Chinonyerem O. Iheanacho, Valentine U. Odili and Uchenna I. H. Eze

Ethnomedicinal herbs in African traditional medicine with potential activity for the prevention, treatment, and management of coronavirus disease 2019

Ethnomedicine, a study of traditional medicine, is significant in drug discovery and development. African traditional medicine has been in existence for several thousands of years, and several drugs have been ...

Authors: Olutayo Ademola Adeleye, Mbang Nyong Femi-Oyewo, Oluyemisi Adebowale Bamiro, Lateef Gbenga Bakre, Akinyinka Alabi, Joseph Senu Ashidi, Olalekan Adeyinka Balogun-Agbaje, Oluwakemi Mary Hassan and Gbemisola Fakoya

Scrutinizing pharmacological efficiency for Acacia auriculiformis by experimental and computational approach

The study sought to investigate the biological efficacy of methanol leave extract of Acacia auriculiformis (MEAA) via in vitro, in vivo, in silico approaches. The in vitro cytotoxicity was evaluated through brine...

Authors: Shafinaz Nur, Md. Mohotasin Hossain, Nadia Islam, Abu Montakim Tareq, Nujhat Binte Hanif, Riniara Khatun and Mohammed Abu Sayeed

Anticancer activity of Nigerian medicinal plants: a review

Cancer is currently the leading cause of death globally and the number of deaths from cancer is on the rise daily. Medicinal plants have been in continuous use over the years for the management of cancer, part...

Authors: Franklyn O. Ohiagu, Paul C. Chikezie, Chinwendu M. Chikezie and Christian E. Enyoh

Chemopreventive potential of plant-derived epigenetic inhibitors silibinin and quercetin: an involvement of apoptotic signaling cascade modulation

Epigenetic deregulation of the cellular apoptotic mechanism is the common hallmark of cancer. Silibinin (SBN) and quercetin (QCT) are two bioflavonoids well known for their epigenetic inhibition property. The ...

Authors: Ruma Baksi, Rita Rana and Manish Nivsarkar

Comparative Antioxidant Analysis of Moringa oleifera Leaf Extracts from South Western States in Nigeria

Moringa oleifera is a medicinal plant that ethnobotanical studies have shown its inclusion in treatment of many ailments such as diarrhea, diabetes, epilepsy, wound healing and arthritis. It is a plant that was b...

Authors: Ayonposi Bukola Olaoye, Charles Ayorinde Ologunde, Olorunfemi Raphael Molehin and Ikechukwu Nwankwo

Therapeutic role of corticosteroids in COVID-19: a systematic review of registered clinical trials

In March 2020, the World Health Organization declared the coronavirus disease 2019 as a global pandemic. Though antiviral drugs and antimalarial drugs are considered treatment options for treating coronavirus ...

Authors: Reshma Raju, Prajith V., Pratheeksha Sojan Biatris and Sam Johnson Udaya Chander J.

Neurodegenerative disorders associated with genes of mitochondria

Over the last decade, aggregating evidences suggested that there is a causative link between mutation in gene associated with mitochondrial dysfunction and development of several neurodegenerative disorders.

Authors: Vaibhav S. Marde, Prerna L. Tiwari, Nitu L. Wankhede, Brijesh G. Taksande, Aman B. Upaganlawar, Milind J. Umekar and Mayur B. Kale

A review on the phytochemical and pharmacological properties of Hyptis suaveolens (L.) Poit

Plants are the repository of variable number of valuable secondary metabolites that bears pharmacognostic and pharmacological implications having potentiality to emerge as super drugs in future. In-vivo produc...

Authors: Pratibha Mishra, Saima Sohrab and Sanjay Kumar Mishra

Rosuvastatin cocrystals: an attempt to modulate physicochemical parameters

The meager physicochemical properties like low solubility and low dissolution rate of rosuvastatin calcium remain as an obstruction for formulation development. In the present work, we explore the evolution of...

Authors: Venkata Deepthi Vemuri and Srinivas Lankalapalli

Unveiling novel inhibitors of dopamine transporter via in silico drug design, molecular docking, and bioavailability predictions as potential antischizophrenic agents

The inhibition of dopamine transporter is known to play a significant role in the treatment of schizophrenia-related and other mental disorders. In a continuing from our previous study, computational drug desi...

Authors: Sabitu Babatunde Olasupo, Adamu Uzairu, Gideon Adamu Shallangwa and Sani Uba

Discovery of Bis-sydnone styryl ketone as a selective cyclooxygenase-2 inhibitor

Various literature sources have documented a wide spectrum of therapeutic properties of sydnones including anti-inflammatory, anticancer, antimicrobial activities. Phenyl styryl ketones and their derivatives a...

Authors: Abdualrahman Mohammed Abdualkader, Muhammad Taher, Nik Idris Nik Yusoff and Mohamed Alaama

Ethyl acetate fraction of Cola hispida leaf protects against doxorubicin-induced myocardial injury in male albino rats

Cardiovascular diseases have continued to be the leading cause of death globally. In addition, some of the drugs used in the treatment of the diseases present some adverse effects which limit the usefulness of...

Authors: Chiemeka Lynda Umenwanne, Martins Obinna Ogugofor and Obioma U. Njoku

Impact of silver nanoparticles as antibacterial agent derived from leaf and callus of Celastrus paniculatus Willd

Celastrus paniculatus Willd. is a rich source of numerous active constituents such as celapanigin, celapagin, malkangunin, celapanin, zeylasteral, pristimerin, and zeylasterone which render medicinal properties t...

Authors: Anita Solanki, Dipika Rathod, Illa C. Patel and Jitendriya Panigrahi

Phytochemical profiling and GC-MS analysis of aqueous methanol fraction of Hibiscus asper leaves

Medicinal plants are of great importance to researchers in the field of pharmacology as most pharmaceutical industries depend on medicinal plant for their raw materials. Hibiscus asper belongs to the family Malva...

Authors: Njoku Ugochi Olivia, Umeh Chinenyenwa Goodness and Ogugofor Martins Obinna

Isolation, identification, and cytotoxicity evaluation of phytochemicals from chloroform extract of Spathodea campanulata

Spathodea campanulata P. Beauv. known as the African tulip tree has potential medicinal properties that have been shown traditionally for the treatment of various ailments. The aim of the present study was isolat...

Authors: Anita Wagh, Santosh Butle and Dipak Raut

Development, optimization and characterization of flurbiprofen matrix transdermal drug delivery system using Box–Behnken statistical design

Present investigation for research was to develop matrix-type transdermal drug delivery system of flurbiprofen (FBP) with the various ratio of matrix polymers (hydrophilic and hydrophobic), the concentration o...

Authors: Ramakant Joshi and Navneet Garud

Insights on recent approaches in drug discovery strategies and untapped drug targets against drug resistance

Despite the various strategies undertaken in the clinical practice, the mortality rate due to antibiotic-resistant microbes has been markedly increasing worldwide. In addition to multidrug-resistant (MDR) micr...

Authors: Ramalingam Peraman, Sathish Kumar Sure, V. N. Azger Dusthackeer, Naresh Babu Chilamakuru, Padmanabha Reddy Yiragamreddy, Chiranjeevi Pokuri, Vinay Kumar Kutagulla and Santhivardhan Chinni

Embelin: an HPTLC method for quantitative estimation in five species of genus Embelia Burm. f.

The plants belonging to the genus Embelia, a significant tropical genus with many biological activities, are benefiting because of their robust medicinal properties. Embelin is one of the principal bioactive mole...

Authors: K. P. Rini Vijayan and A. V. Raghu

Pharmaceutical applications of citric acid

Citric acid (CA) is a universal plant and animal-metabolism intermediate. It is a commodity chemical processed and widely used around the world as an excellent pharmaceutical excipient. Notably, CA is offering...

Authors: Sopan Nangare, Yogini Vispute, Rahul Tade, Shailesh Dugam and Pravin Patil

Medicinal plants and their components for wound healing applications

Wound is an anatomical and functional disruption of the skin following an injury. In response to the injury, wound healing is a complex process of tissue repair or remodeling. Historically, plants and plant-ba...

Authors: Akshay Sharma, Suryamani Khanna, Gaganjot Kaur and Inderbir Singh

Phytochemical comparison and evaluation of anti-inflammatory and anti-diabetic activity of three source plants of Jivanti-an important Ayurvedic drug

In Ayurveda, Jivanti is an important Rasayana drug that increases the energy level of the body. The botanical source of Jivanti is in a situation of controversy. The root of Leptadenia reticulata is the genuine s...

Authors: Sulaiman C. T., Jyothi C. K., Jinu Krishnan Unnithan G., Prabhukumar K. M. and Indira Balachandran

Synthesis, characterization, and biological studies of some biometal complexes

Metal complexes Cu[C₁₃H₈O₄N]₂ 2, Ni[C_l3H₈O₄N]₂ 3, and Co[C₁₃H₈O₄N]₂ 4 of bioinorganic relevance have been synthesized with the Schiff base ligand 2-furylglyoxal–anthranilic acid (FGAA) [C₁₃H₉O₄N] 1.

Authors: Vinay Kumar Srivastava

Evaluation of in vitro cytotoxic activity of different solvent extracts of Clerodendrum thomsoniae Balf.f and its active fractions on different cancer cell lines

Clerodendrum is a genus of about 500 species belongs to the family Lamiaceae. Many species of this genus have been proved for the treatment of various diseases. This study was aimed to evaluate the cytotoxic effe...

Authors: V. K. Muhammed Ashraf, V. K. Kalaichelvan, V. V. Venkatachalam and R. Ragunathan

Analytical method development and validation for simultaneous estimation of monoammonium glycyrrhizinate and sennoside-B in polyherbal laxative tablet using RP-HPLC

Standardization of polyherbal medicine though being the need of the hour is a toilsome task. Among the various methods employed for quality control and standardization of polyherbal medicine, phytochemical pro...

Authors: Madhavi Patel, Shivangi Chauhan, Vishal Patel, Hardik Soni and Vikram Trivedi

A phytomass-inspired carbon and its importance as an antibacterial agent against human pathogens

Imprudent use of antimicrobial drugs has resulted in the microbial resistance among the known microbes and hence we foresee a pressing need towards the development of novel, low-cost, and high potent antimicro...

Authors: N. Anvarsha and P. Kalyani

Professor Osama Salama obituary

Authors: