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Future Journal of Pharmaceutical Sciences

Table 8 Robustness study of developed analytical method

From: Simultaneous estimation for Dicyclomine HCl and Simethicone in bulk and oral liquid drop formulation: an RP-HPLC method development and validation

Analyst

Dicyclomine HCl

Simethicone

AUC

Retention time

Peak area

Retention time

I

6186

2.955

317,382

4.081

6204

2.953

319,609

4.088

6257

2.96

316,292

4.093

6192

2.959

319,508

4.083

6217

2.955

319,723

4.085

Mean ± SD

6211.2 ± 28.22

2.956 ± 0.0

318,502.8 ± 1570.57

4.086 ± 0.0

% RSD

0.45

0.10

0.49

0.11

II

5998

2.959

315,633

4.083

6022

2.954

312,912

4.094

6058

2.955

312,634

4.086

6047

2.964

313,893

4.084

5989

2.959

311,283

4.086

Mean ± SD

6022.8 ± 29.92

2.958 ± 0.0

313,271 ± 1616.53

4.086 ± 0.0

% RSD

0.49

0.13

0.51

0.10

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