Future Journal of Pharmaceutical Sciences

Table 9: Summary of validation parameters

From: Simultaneous estimation for Dicyclomine HCl and Simethicone in bulk and oral liquid drop formulation: an RP-HPLC method development and validation

Parameters	Dicyclomine HCl	Simethicone
Linearity range (ng/ml)	5–40 μg/ml	5–40 μg/ml
Regression equation	Y = 0.1494X + 0.0007	Y = 0.7418X − 0.0039
Correlation Coefficient (r²)	0.9995	0.9991
Accuracy (% RSD)	0.95	1.30
Precision (% RSD)	0.42	0.45
Repeatability (n = 5)
Intra-day (n = 3)	0.48	0.50
Inter-day (n = 3)	0.49	0.49
Robustness
Analyst I (n = 6)	0.45	0.49
Analyst II (n = 6)	0.49	0.51
LOD (μg/ml)	0.72	0.57
LOQ (μg/ml)	2.19	1.73

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